Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C) (CAT#: PABL-180)
Recombinant Human Antibody (VRC08C) is capable of binding to HIV-1 gp160, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp160 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp160 mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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Figure 1 Isolation of antigen-specific antibodies by sorting of donor 45.
B cells were probed either with RSC3 and its ΔI371 mutant ΔRSC3 or with a modified outer domain OD4.2 protein HG3.2 and its D368R mutant ΔHG3.2. Indicated in red is the percentage of total IgG+ B cells defined as probe-specific in each gate.
Wu, X., Zhang, Z., Schramm, C. A., Joyce, M. G., Do Kwon, Y., Zhou, T.,... & Georgiev, I. S. (2015). Maturation and diversity of the VRC01-antibody lineage over 15 years of chronic HIV-1 infection. Cell, 161(3), 470-485.
Figure 2 VRC08 neutralization dendrogram of 195 HIV-1 Env pseudoviruses with branches colored by potency.
Wu, X., Zhang, Z., Schramm, C. A., Joyce, M. G., Do Kwon, Y., Zhou, T.,... & Georgiev, I. S. (2015). Maturation and diversity of the VRC01-antibody lineage over 15 years of chronic HIV-1 infection. Cell, 161(3), 470-485.
Specifications
- Host Species
- Human
- Type
- Human IgG, κ
- Species Reactivity
- HIV-1
- Clone
- VRC08C
- Applications
- WB, ELISA, Neut, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Neut. For details, refer to published data.
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160; precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-163 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 268-D); Fab Fragment | ELISA, Neut | Human Fab |
| MRO-3674CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone HGN35); scFv Fragment | ELISA | Human scFv |
| MRO-3675CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 10-188); scFv Fragment | ELISA, Neut | Human scFv |
| MRO-3676CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 10-380); scFv Fragment | Neut | Human scFv |
| MRO-3677CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 10J4); scFv Fragment | Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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