Recombinant Human Anti-HSV gD Antibody (mAb E317) (CAT#: PABL-579)
Recombinant Human Antibody (mAb E317) is capable of binding to HSV gD , expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HSV gD mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HSV gD proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The highly inhibitory human monoclonal antibody E317 was previously raised against HSV gD for viral neutralization. E317 interacts with gD mainly through the heavy chain, which covers a large area for epitope recognition on gD, with a flexible N-terminal and C-terminal conformation.
Specific Inquiry
Figure 1 Crystal structure of HSV-2 gD–E317-Fab.
Ribbon representation of HSV-2 gD (residues 25–254). Disulfide bonds, two glycosylation sites (Asn94 and Asn121) and the secondary-structure elements are labelled. The inset shows the Asn94-linked N-acetylglucosamine (GlcNAc) bound to Gln41.
Lee, C. C., Lin, L. L., Chan, W. E., Ko, T. P., Lai, J. S., & Wang, A. J. (2013). Structural basis for the antibody neutralization of herpes simplex virus. Acta Crystallographica Section D: Biological Crystallography, 69(10), 1935-1945.
Specifications
- Immunogen
- Human glycoprotein D
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native HSV gD
- Species Reactivity
- HSV
- Clone
- mAb E317
- Applications
- WB 1:1000-1:10000
IF Assay-depended
FuncS Assay-depended
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- HSV gD; herpes simplex virus glycoprotein D; gD; glycoprotein D; HSV; herpes simplex virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
ScFv Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-574 | Recombinant Human Anti-HSV gD Antibody Fab Fragment (E317) | WB, IF, FuncS | Fab |
| FAMAB-0199WJ-F(E) | Mouse Anti-HSV gD Recombinant Antibody (clone Fd138-80); Fab Fragment | ELISA, WB, Neut | Mouse Fab |
| FAMAB-0200WJ-F(E) | Human Anti-HSV gD Recombinant Antibody (clone HuFd138-80); Fab Fragment | ELISA, WB, Neut | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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