anti-KMA immunotoxin K121 (scFv)-Mel (CAT#: AGTO-L030M)
This immunotoxin was achieved by conjugating/fusing the Anti-KMA scFv to melittin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to myeloma and lymphoma cells. Once bind, melittin is subsequently incorporated into the cell by receptor-mediated endocytosis and inhibits activities of protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane). It was designed for treatment of myeloma and lymphoma.
Specific Inquiry
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- K121
- Molecule Class
- scFv-Mel
- Toxin Description
- Melittin is the principal active component of apitoxin (bee venom) and is a powerful stimulator of phospholipase A2. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. Melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane) and is a cell membrane lytic factor. Melittin is a small peptide with no disulphide bridge; the N-terminal part of the molecule is predominantly hydrophobic and the C-terminal part is hydrophilic and strongly basic.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Myeloma and lymphoma
Target
- Alternative Names
- kappa myeloma antigen; KMA; Myeloma; lymphoma; Melittin; apitoxin; bee venom; Mel
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone K121"
See other products for "KMA"
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-475CL | mouse Anti-KMA Recombinant Antibody (TAB-475CL) | Cyt, FC | mouse IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0630CL | Anti-Human KMA Recombinant Antibody (cK121) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-0630CL-S(P) | Anti-Human KMA Recombinant Antibody scFv Fragment (cK121) | ELISA, FC | Chimeric antibody (mouse/human) |
| TAB-0630CL-F(E) | Anti-Human KMA Recombinant Antibody Fab Fragment (cK121) | ELISA, FC | Chimeric antibody (mouse/human) |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AGTO-L030M. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.