Anti-Human LRRN1 Recombinant Antibody (TB0777#281-6 (N1mAb)) (CAT#: TAB-522MZ)
This antibody recognizes human LRRN1 (Leucine-rich-repeat-neuronal protein-1), also called NLRR1 (Neuronal leucine-rich repeat protein 1). This antibody binds to the Ig domain and fibronectin type III domain of LRRN1 as measured by flow cytometry. The antibody showed a cell growth inhibitory effect.
Specific Inquiry
Figure 1 A is a SY5Y-ctrl, B is a result of SY5Y-N1.
It shows cell growth inhibitory effect of anti NLRR1 monoclonal antibody (NLRR1 mAb # 281-6) in NB and non NB cells.
Figure 2 It shows that the treatment with N1mAb antibody (# 281-6) was significantly inhibited the growth of xenograft tumors.
Open circles are saline, the black circles is an antibody.
Figure 3 It shows that the treatment with N1mAb antibody (# 281-6) was significantly inhibited the growth of xenograft tumors.
Open circles are saline, the black circles is an antibody.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- TB0777 # 281-6 (N1mAb)
- Applications
- ELISA, FC, Inhib, FuncS
- Related Disease
- Cancers including neuroblastoma, pulmonary cancer, mammary cancer
Applications
- Application Notes
- The antibody was validated for Inhibition and Function assay. For details, refer to Published Data.
Target
Related Resources
Wei, Yun, et al. "Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma." Nature cancer 3.8 (2022): 961-975. https://doi.org/s43018-022-00414-w
This study investigates the conservation of cellular hierarchy and the identification of tumor-propagating cells (TPCs) in rhabdomyosarcoma (RMS) using single-cell RNA sequencing, DNA-barcode cell fate mapping, and functional stem cell assays. The research uncovers shared tumor cell hierarchies in RMS and human muscle development, identifying common developmental stages where tumor cells become arrested. It highlights the molecularly-defined TPCs in fusion-negative RMS (FN-RMS) that resemble early myogenic cells found in embryonic and fetal development. These TPCs are quiescent under normal conditions but can re-enter the cell cycle to drive tumor growth under stress or in vivo conditions.
Creative Biolabs provided crucial reagents for this study, specifically the anti-LRRN1 antibody (Cat# TAB-522MZ). These antibodies were essential for the fluorescence-activated cell sorting (FACS) used to isolate mesenchymal-like and differentiated muscle cell populations. By enabling the identification and enrichment of specific cell states within FN-RMS, these reagents facilitated the detailed characterization of TPCs and their role in tumor growth and maintenance, supporting the study's exploration of cellular hierarchies in RMS.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-522MZ-S(P) | Anti-Human LRRN1 Recombinant Antibody scFv Fragment (TB0777#281-6 (N1mAb)) | ELISA, FC | |
| TAB-522MZ-F(E) | Anti-Human LRRN1 Recombinant Antibody Fab Fragment (TB0777#281-6 (N1mAb)) | ELISA, FC |
Customer Reviews and Q&As
Customer Review
Q&As
David Evans
Excellent for LRRN1 Research
Excellent for LRRN1 Research
The Anti-LRRN1 Therapeutic Antibody has been excellent for our LRRN1 studies. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.
10-Sep-23
Laura Baker
Effective in Immunoassays
Effective in Immunoassays
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for LRRN1 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.
08-Nov-22
Jessica Turner
Consistent and High-Quality
Consistent and High-Quality
This antibody has proven to be consistent and high-quality in our various assays. The reproducible results and strong affinity for LRRN1 have significantly improved our experiments, making it a crucial part of our research toolkit. The consistent performance has greatly enhanced our data quality.
03-Aug-21
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-522MZ, RRID: AB_3111968)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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