Anti-Human LRRN1 Recombinant Antibody (TB0777#281-6 (N1mAb))

Customer Review

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David Evans
10.Sep,23

Excellent for LRRN1 Research

The Anti-LRRN1 Therapeutic Antibody has been excellent for our LRRN1 studies. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.

Laura Baker
08.Nov,22

Effective in Immunoassays

We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for LRRN1 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.

Jessica Turner
03.Aug,21

Consistent and High-Quality

This antibody has proven to be consistent and high-quality in our various assays. The reproducible results and strong affinity for LRRN1 have significantly improved our experiments, making it a crucial part of our research toolkit. The consistent performance has greatly enhanced our data quality.

Q&As

1. Is the anti-LRRN1 therapeutic antibody suitable for flow cytometry analysis?

   A: Yes, the anti-LRRN1 therapeutic antibody (TAB-522MZ) is suitable for flow cytometry analysis. It is designed to specifically bind to LRRN1, making it suitable for detecting LRRN1-expressing cells in flow cytometry.

2. What are the recommended storage conditions for the anti-LRRN1 therapeutic antibody?

   A: The recommended storage condition for the anti-LRRN1 therapeutic antibody (TAB-522MZ) is at -20°C or lower. For short-term storage, it can be kept at 2-8°C. To ensure stability, avoid repeated freeze-thaw cycles.

3. Can the anti-LRRN1 therapeutic antibody be used in immunoprecipitation assays?

   A: Yes, the anti-LRRN1 therapeutic antibody (TAB-522MZ) can be used in immunoprecipitation assays. It provides specific binding to LRRN1, enabling the successful precipitation of the target protein from complex mixtures.

4. Is the anti-LRRN1 therapeutic antibody effective in ELISA applications?

   A: Yes, the anti-LRRN1 therapeutic antibody (TAB-522MZ) is effective in ELISA applications. It has been validated for use in such assays and provides reliable detection of LRRN1.

5. What is the optimal dilution for using the anti-LRRN1 therapeutic antibody in Western blotting?

   A: The optimal dilution for using the anti-LRRN1 therapeutic antibody (TAB-522MZ) in Western blotting is typically 1:500 to 1:2000. It is advisable to perform a dilution series to determine the best working concentration for your specific experimental conditions.

View the frequently asked questions answered by Creative Biolabs Support.

Citations

1. Wei, Yun, et al. "Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma." Nature cancer 3.8 (2022): 961-975. https://doi.org/s43018-022-00414-w
   This study investigates the conservation of cellular hierarchy and the identification of tumor-propagating cells (TPCs) in rhabdomyosarcoma (RMS) using single-cell RNA sequencing, DNA-barcode cell fate mapping, and functional stem cell assays. The research uncovers shared tumor cell hierarchies in RMS and human muscle development, identifying common developmental stages where tumor cells become arrested. It highlights the molecularly-defined TPCs in fusion-negative RMS (FN-RMS) that resemble early myogenic cells found in embryonic and fetal development. These TPCs are quiescent under normal conditions but can re-enter the cell cycle to drive tumor growth under stress or in vivo conditions.
   Creative Biolabs provided crucial reagents for this study, specifically the anti-LRRN1 antibody (Cat# TAB-522MZ). These antibodies were essential for the fluorescence-activated cell sorting (FACS) used to isolate mesenchymal-like and differentiated muscle cell populations. By enabling the identification and enrichment of specific cell states within FN-RMS, these reagents facilitated the detailed characterization of TPCs and their role in tumor growth and maintenance, supporting the study's exploration of cellular hierarchies in RMS.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-522MZ, RRID: AB_3111968)

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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