Anti-Human MC4R Recombinant Antibody (1E8a) (CAT#: TAB-0733CL)
Recombinant monoclonal antibody 1E8a is a mouse monoclonal antibody that specifically binds to human MC4R and can be potentially used in the treatment of cachexia.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
ICC
Figure 1 Immunocytochemistry of HEK-293 cells transfected with hMC4R or hMC3R.
The specific membrane labeling was seen in HEK-293 cells expressing hMC4R when incubated with the mAb 1E8a.
Peter, J. C., Lecourt, A. C., Weckering, M., Zipfel, G., Niehoff, M. L., Banks, W. A., & Hofbauer, K. G. (2010). A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Journal of pharmacology and experimental therapeutics, 333(2), 478-490.
IP
Figure 2 The inhibition of hMC4R immunoprecipitation by mAb 1E8a using increasing concentration of the NT peptide.
Results are presented as percentage of inhibition of the
signal obtained without NT peptide in function of the [NT].
Mean=S.D. are calculated from three independent experiments.
n=5 measurements/experiment.
Peter, J. C., Lecourt, A. C., Weckering, M., Zipfel, G., Niehoff, M. L., Banks, W. A., & Hofbauer, K. G. (2010). A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Journal of pharmacology and experimental therapeutics, 333(2), 478-490.
WB
Figure 3 Western blot probed with an anti-His6 Ab that revealed the presence of the His6-tagged scFv 1E8a.
Purification of the scFv 1E8a by Ni-NTA chromatography.
Peter, J. C., Lecourt, A. C., Weckering, M., Zipfel, G., Niehoff, M. L., Banks, W. A., & Hofbauer, K. G. (2010). A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Journal of pharmacology and experimental therapeutics, 333(2), 478-490.
Specifications
- Immunogen
- Free peptide NT4
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 1E8a
- Applications
- ICC, IP, WB
- Related Disease
- Cachexia
Applications
- Application Notes
- The MC4R antibody has been reported in applications of Immunocytochemistry, Immunoprecipitation, Western Blot.
Target
- Alternative Names
- MC4R; melanocortin 4 receptor; melanocortin receptor 4; MC4-R
- Gene ID
- 4160
- UniProt ID
- P32245
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1714-sdAb | Recombinant Anti-Human MC4R VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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