Human Anti-MERS-CoV S Recombinant Antibody (clone MERS-27) (CAT#: PABL-327)
Recombinant Human Antibody (MERS-27) is capable of binding to S protein, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-S protein mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-S protein mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Figure 1 The percent neutralization, fractional effect, and CI values for MERS-4 combined with 5F9 (B) and MERS-4 combined with MERS-27 (C) were calculated and generated using the same method.
Zhang, S., Zhou, P., Wang, P., Li, Y., Jiang, L., Jia, W.,... & Fang, X. (2018). Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein. Cell reports, 24(2), 441-452.
Figure 2 Neutralizing activities of MERS-27 against infection of MERS-CoV pseudoviruses bearing wild type or mutant spike glycoprotein into Huh7 cells.
Yu, X., Zhang, S., Jiang, L., Cui, Y., Li, D., Wang, D.,... & Zhang, L. (2015). Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27.Scientific reports, 5, 13133.
Figure 3 Binding affinities of wild-type and mutant RBD with MERS-27 Fab.
Yu, X., Zhang, S., Jiang, L., Cui, Y., Li, D., Wang, D.,... & Zhang, L. (2015). Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27.Scientific reports, 5, 13133.
Specifications
- Immunogen
- MERS-CoV Spike glycoprotein
- Host Species
- Human
- Type
- Human IgG
- Specificity
- MERS-CoV S protein
- Species Reactivity
- MERS-CoV
- Clone
- MERS-27
- Applications
- Neut, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- S protein; Spike glycoprotein
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-324 | Mouse Anti-MERS-CoV S Recombinant Antibody (clone 4C2); scFv Fragment | WB, ELISA, Neut, FuncS | Mouse scFv |
| PSBL-325 | Mouse Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (PSBL-325) | Neut, FC, ELISA, FuncS | Mouse scFv |
| PSBL-326 | Human Anti-MERS-CoV S Recombinant Antibody (clone m336); scFv Fragment | WB, Neut, FuncS | Human scFv |
| PSBL-327 | Human Anti-MERS-CoV S Recombinant Antibody (clone MERS-27); scFv Fragment | Neut, FuncS | Human scFv |
| PABJ-0206-S(P) | Human Anti-MERS-CoV S Recombinant Antibody (clone LCA60); scFv Fragment | Neut | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-880LC | Mouse Anti-MERS-CoV S Recombinant Antibody (MRO-880LC) | ELISA | Mouse antibody |
| MRO-881LC | Mouse Anti-MERS-CoV S Recombinant Antibody (MRO-881LC) | ELISA | Mouse antibody |
| MRO-880LC-S(P) | Mouse Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-880LC-S(P)) | ELISA | Mouse scFv |
| MRO-880LC-F(E) | Mouse Anti-MERS-CoV S Recombinant Antibody; Fab Fragment (MRO-880LC-F(E)) | ELISA | Mouse Fab |
| MRO-881LC-F(E) | Mouse Anti-MERS-CoV S Recombinant Antibody; Fab Fragment (MRO-881LC-F(E)) | ELISA | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-886LC-S(P) | Human Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-886LC-S(P)) | ELISA | Human scFv |
| MRO-887LC-S(P) | Human Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-887LC-S(P)) | ELISA | Human scFv |
| MRO-888LC-S(P) | Human Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-888LC-S(P)) | ELISA | Human scFv |
| MRO-889LC-S(P) | Human Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-889LC-S(P)) | ELISA | Human scFv |
| MRO-890LC-S(P) | Human Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-890LC-S(P)) | ELISA | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-274 | Recombinant Human Anti-MERS-CoV S Antibody (MCA1) | ELISA, Neut, FuncS | Human IgG |
| HPAB-M0145-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-1) | ELISA, Neut | Humanized IgG |
| HPAB-M0146-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-2) | ELISA, Neut | Humanized IgG |
| HPAB-M0147-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-3) | ELISA, Neut | Humanized IgG |
| HPAB-M0148-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-4) | ELISA, Neut | Humanized IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0145-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-1) | ELISA, Neut | Humanized Fab |
| HPAB-M0146-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-2) | ELISA, Neut | Humanized Fab |
| HPAB-M0147-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-3) | ELISA, Neut | Humanized Fab |
| HPAB-M0148-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-4) | ELISA, Neut | Humanized Fab |
| HPAB-M0149-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (24F2-1) | ELISA, Neut | Humanized Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-470CQ | Camelid Anti-MERS-CoV S Recombinant Single Domain Antibody (clone VHH-12) | ELISA, Neut | Camelid VHH |
| NAB-471CQ | Camelid Anti-MERS-CoV S Recombinant Single Domain Antibody (clone VHH-34) | ELISA, Neut | Camelid VHH |
| NAB-472CQ | Camelid Anti-MERS-CoV S Recombinant Single Domain Antibody (clone VHH-40) | ELISA, Neut | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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