This product is a recombinant Human antibody that can recognize MERS-CoV S. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). This antibody is a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets.
Figure 1 MCA1 neutralized Middle East respiratory syndrome coronavirus (MERS-CoV) in vitro.
The neutralizing activities of MCA1 against MERS-CoV were examined using Vero E6 cells. An irrelevant human immunoglobulin G (IgG) was used as a control.
Chen, Z., Bao, L., Chen, C., Zou, T., Xue, Y., Li, F., ... & Wang, J. (2017). Human neutralizing monoclonal antibody inhibition of Middle East respiratory syndrome coronavirus replication in the common marmoset. The Journal of infectious diseases, 215(12), 1807-1815.
Figure 2 Prophylactic efficacy of MCA1 in common marmosets, which were intravenously inoculated with the antibody at doses of 5 mg/kg (designated G1) and 20 mg/kg (G2) and then challenged with Middle East respiratory syndrome coronavirus (MERS-CoV) 24 hours later.
A control group was simultaneously infected and set up as a model (M) group. All groups were monitored twice daily for 3 days. A, Clinical scores (n = 3 per group). B, Temperature changes (n = 3 per group). C, Mean body weight changes (n = 3 per group). Results are presented as means with standard deviations. *P < .05 (t test).
Chen, Z., Bao, L., Chen, C., Zou, T., Xue, Y., Li, F., ... & Wang, J. (2017). Human neutralizing monoclonal antibody inhibition of Middle East respiratory syndrome coronavirus replication in the common marmoset. The Journal of infectious diseases, 215(12), 1807-1815.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-880LC | Mouse Anti-MERS-CoV S Recombinant Antibody (MRO-880LC) | ELISA | Mouse antibody |
MRO-881LC | Mouse Anti-MERS-CoV S Recombinant Antibody (MRO-881LC) | ELISA | Mouse antibody |
MRO-880LC-S(P) | Mouse Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-880LC-S(P)) | ELISA | Mouse scFv |
MRO-881LC-S(P) | Mouse Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-881LC-S(P)) | ELISA | Mouse scFv |
MRO-880LC-F(E) | Mouse Anti-MERS-CoV S Recombinant Antibody; Fab Fragment (MRO-880LC-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-886LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-886LC) | ELISA | Human IgG |
MRO-887LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-887LC) | ELISA | Human IgG |
MRO-888LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-888LC) | ELISA | Human antibody |
MRO-889LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-889LC) | Neut | Human antibody |
MRO-890LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-890LC) | Neut | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-2251CQ | Recombinant Mouse Anti-MERS-CoV S Antibody (4) | ELISA, WB, IHC-P, IF/ICC, IP | Mouse antibody |
HPAB-M0145-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-1) | ELISA, Neut | Humanized IgG |
HPAB-M0146-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-2) | ELISA, Neut | Humanized IgG |
HPAB-M0147-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-3) | ELISA, Neut | Humanized IgG |
HPAB-M0148-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-4) | ELISA, Neut | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-274 | Recombinant Human Anti-MERS-CoV S Antibody scFv Fragment (MCA1) | ELISA, Neut | Human scFv |
HPAB-M0145-YC-S(P) | Recombinant Humanized Anti-MERS-Cov S Antibody scFv Fragment (11F11-1) | ELISA, Neut | Humanized scFv |
HPAB-M0146-YC-S(P) | Recombinant Humanized Anti-MERS-Cov S Antibody scFv Fragment (11F11-2) | ELISA, Neut | Humanized scFv |
HPAB-0310-YJ-S(P) | Human Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (HPAB-0310-YJ-S(P)) | ELISA, Neut, FuncS | Human scFv |
PABJ-0206-S(P) | Human Anti-MERS-CoV S Recombinant Antibody (clone LCA60); scFv Fragment | Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0145-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-1) | ELISA, Neut | Humanized Fab |
HPAB-M0146-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-2) | ELISA, Neut | Humanized Fab |
HPAB-M0147-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-3) | ELISA, Neut | Humanized Fab |
HPAB-M0148-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-4) | ELISA, Neut | Humanized Fab |
PABJ-0206-F(E) | Human Anti-MERS-CoV S Recombinant Antibody (clone LCA60); Fab Fragment | Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-470CQ | Camelid Anti-MERS-CoV S Recombinant Single Domain Antibody (clone VHH-12) | ELISA, Neut | Camelid VHH |
NAB-471CQ | Camelid Anti-MERS-CoV S Recombinant Single Domain Antibody (clone VHH-34) | ELISA, Neut | Camelid VHH |
NAB-472CQ | Camelid Anti-MERS-CoV S Recombinant Single Domain Antibody (clone VHH-40) | ELISA, Neut | Camelid VHH |
There are currently no Customer reviews or questions for PABC-274. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.