Anti-Human NGF Therapeutical Antibody (PG110) (CAT#: TAB-686CL)

Recombinant Humanized monoclonal antibody expressed in CHO binding to Human NGF. PG110 is a monoclonal antibody that inhibits the effects of the naturally occurring substance, nerve growth factor (NGF). Phase I study to evaluate the safety, tolerability, and pharmacokinetics of PG110 (Anti-NGF Monoclonal Antibody) in patients with pain attributed to osteoarthritis of the knee.


Specific Inquiry
  • Size:
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  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
FuncS

Figure 1 Effects of PG110 on CFA-induced heat and mechanical hypersensitivity.

Figure 1 Effects of PG110 on CFA-induced heat and mechanical hypersensitivity.

CFA treatment significantly decreased the mean ipsilateral PWL 5 days post treatment in 36 rats that were divided into four groups.

Djouhri, L. (2016). PG110, a humanized anti-NGF antibody, reverses established pain hypersensitivity in persistent inflammatory pain, but not peripheral neuropathic pain, rat models. Pain Medicine, 17(11), 2082-2094.


Specifications

  • Derivation
  • Humanized
  • Type
  • Antibody
  • Species Reactivity
  • Human
  • Applications
  • FuncS
  • Related Disease
  • Osteoarthritis

Product Property

  • Purity
  • >95% by HPLC
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Applications

  • Application Notes
  • This antibody has been tested for use in Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

  • Alternative Names
  • NGF; Beta-NGF; HSAN5; NGFB

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Ngf"

Humanized Antibody

CAT Product Name Application Type
TAB-111 Anti-Human NGF Recombinant Antibody (Tanezumab) ELISA, FuncS, Inhib IgG2
TAB-501MZ Anti-Human NGF Recombinant Antibody (αD11. H67) ELISA Humanized antibody
TAB-501MZ-S(P) Anti-Human NGF Recombinant Antibody scFv Fragment (αD11. H67) ELISA, IRMA, RIA, IHC Humanized antibody
TAB-501MZ-F(E) Anti-Human NGF Recombinant Antibody Fab Fragment (αD11. H67) ELISA, IRMA, RIA, IHC Humanized antibody

Recombinant Antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0852MZ Chicken Anti-NGF Polyclonal IgY ELISA Chicken antibody
BRD-1134MZ Chicken Anti-Beta NGF Polyclonal IgY ELISA, WB, IHC Chicken antibody

Rabbit Monoclonal Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1768CQ Recombinant Mouse Anti-NGF Antibody (aD11) IF, BL, ELISA, IHC IgG1, κ
NEUT-1772CQ Recombinant Mouse Anti-NGF Antibody (25623.1) Dot, ELISA, Inhib IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-025ML Afuco™ Anti-NGF ADCC Recombinant Antibody (Frunevetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-031ML Afuco™ Anti-NGF ADCC Recombinant Antibody (Ranevetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-111 Afuco™ Anti-NGF ADCC Recombinant Antibody (Tanezumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-110 Afuco™ Anti-NGF Recombinant Antibody (AFC-TAB-110), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF Human IgG1, κ

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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