Anti-Human NGF Therapeutical Antibody (PG110) (CAT#: TAB-686CL)

Recombinant Humanized monoclonal antibody expressed in CHO binding to Human NGF. PG110 is a monoclonal antibody that inhibits the effects of the naturally occurring substance, nerve growth factor (NGF). Phase I study to evaluate the safety, tolerability, and pharmacokinetics of PG110 (Anti-NGF Monoclonal Antibody) in patients with pain attributed to osteoarthritis of the knee.

Isotype: Antibody

Applications: FuncS


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
FuncS

Figure 1 Effects of PG110 on CFA-induced heat and mechanical hypersensitivity.

CFA treatment significantly decreased the mean ipsilateral PWL 5 days post treatment in 36 rats that were divided into four groups.

Djouhri, L. (2016). PG110, a humanized anti-NGF antibody, reverses established pain hypersensitivity in persistent inflammatory pain, but not peripheral neuropathic pain, rat models. Pain Medicine, 17(11), 2082-2094.


Specifications

  • Derivation
  • Humanized
  • Type
  • Antibody
  • Species Reactivity
  • Human
  • Applications
  • FuncS
  • Related Disease
  • Osteoarthritis

Product Property

  • Purity
  • >95% by HPLC
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Applications

  • Application Notes
  • This antibody has been tested for use in Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

  • Alternative Names
  • NGF; Beta-NGF; HSAN5; NGFB

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "NGF"

Humanized Antibody

CAT Product Name Application Type
TAB-111 Anti-Human NGF Recombinant Antibody (Tanezumab) ELISA, FuncS, Inhib IgG2
TAB-501MZ Anti-Human NGF Recombinant Antibody (αD11. H67) ELISA Humanized antibody
TAB-501MZ-S(P) Anti-Human NGF Recombinant Antibody scFv Fragment (αD11. H67) ELISA, IRMA, RIA, IHC Humanized antibody
TAB-501MZ-F(E) Anti-Human NGF Recombinant Antibody Fab Fragment (αD11. H67) ELISA, IRMA, RIA, IHC Humanized antibody

Human Antibody

CAT Product Name Application Type
TAB-244 Anti-Human HNGF Recombinant Antibody Neut, ELISA, IF, IP, FuncS, FC, ICC IgG4 - kappa
TAB-512MZ Human Anti-NGF Recombinant Antibody (TAB-512MZ) ELISA, RIA, FC, SPR, Inhib Human IgG
TAB-513MZ Human Anti-NGF Recombinant Antibody (TAB-513MZ) ELISA, RIA, FC, SPR, Inhib Human IgG
TAB-512MZ-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (TAB-512MZ-S(P)) ELISA, RIA, FC Human scFv
TAB-513MZ-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (TAB-513MZ-S(P)) ELISA, RIA, FC Human scFv

scFv Fragment Antibody

CAT Product Name Application Type
PSBL-659 Human Anti-NGF Recombinant Antibody (clone APE1531); scFv Fragment WB, FuncS Human scFv
HPAB-0688-CN-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-0688-CN-S(P)) WB, ELISA Human scFv
HPAB-0515LY-S(P) Human Anti-NGF Recombinant Antibody (clone H26L17); scfv Fragment ELISA Human scfv
PSBC-401 Human Anti-NGF Recombinant Antibody (clone MEDI578); scFv Fragment ELISA, IHC Human scFv
HPAB-N0190-YC-S(P) Human Anti-NGF Recombinant Antibody (clone NOV009YC); scFv Fragment ELISA Human scFv

Mouse Antibody

CAT Product Name Application Type
TAB-0331CL-S(P) Mouse Anti-NGF Recombinant Antibody; scFv Fragment (TAB-0331CL-S(P)) Neut, ELISA, Inhib, FuncS Mouse scFv
TAB-500MZ-F(E) Anti-Human NGF Recombinant Antibody Fab Fragment (MNAC13) ELISA, IRMA, RIA, IHC
TAB-502MZ-F(E) Anti-Dog NGF Recombinant Antibody Fab Fragment (NV-01) SDS-PAGE
TAB-503MZ-F(E) Mouse Anti-NGF Recombinant Antibody; Fab Fragment (TAB-503MZ-F(E)) ELISA Mouse Fab
TAB-504MZ-F(E) Mouse Anti-NGF Recombinant Antibody; Fab Fragment (TAB-504MZ-F(E)) ELISA Mouse Fab

Chimeric Antibody

CAT Product Name Application Type
TAB-509MZ Human Anti-NGF Recombinant Antibody (TAB-509MZ) ELISA Chimeric (mouse/human) IgG
TAB-510MZ Human Anti-NGF Recombinant Antibody (TAB-510MZ) ELISA, FuncS Chimeric (mouse/human) IgG
TAB-509MZ-S(P) Mouse Anti-NGF Recombinant Antibody; scFv Fragment (TAB-509MZ-S(P)) ELISA Mouse scFv
TAB-510MZ-S(P) Mouse Anti-NGF Recombinant Antibody; scFv Fragment (TAB-510MZ-S(P)) ELISA Mouse scFv
TAB-509MZ-F(E) Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-509MZ-F(E)) ELISA Chimeric (mouse/human) Fab

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0852MZ Chicken Anti-NGF Polyclonal IgY ELISA Chicken antibody
BRD-1134MZ Chicken Anti-Beta NGF Polyclonal IgY ELISA, WB, IHC Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
PABX-146-S (P) Rat Anti-NGF Recombinant Antibody (clone αD11) Neut, FC, FuncS Rat scFv
MOR-2439 Hi-Affi™ Recombinant Rabbit Anti-NGF Monoclonal Antibody (DS2439AB) WB, ICC, IHC-P, IHC-P IgG

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1764CQ Recombinant Mouse Anti-NGF Antibody (CBL293) Neut IgG1
NEUT-1765CQ Recombinant Mouse Anti-NGF Antibody (12A29) ELISA, Neut IgG1
NEUT-1766CQ Recombinant Mouse Anti-NGF Antibody (M85-2B) ELISA, Neut, WB IgG2b, κ
NEUT-1767CQ Recombinant Mouse Anti-Ngf Antibody (27/21) ELISA, Neut IgG1
NEUT-1769CQ Recombinant Mouse Anti-NGF Antibody (AS18) Neut IgG1

Blocking Antibody

CAT Product Name Application Type
NEUT-1768CQ Recombinant Mouse Anti-NGF Antibody (aD11) IF, BL, ELISA, IHC IgG1, κ
NEUT-1772CQ Recombinant Mouse Anti-NGF Antibody (25623.1) Dot, ELISA, Inhib IgG1

Recombinant Antibody

CAT Product Name Application Type
FAMAB-0028YC Rat Anti-NGF Recombinant Antibody (clone G 30) WB, ICC, FuncS Rat IgG2a
HPAB-0688-CN Human Anti-NGF Recombinant Antibody (HPAB-0688-CN) WB, ELISA Human IgG4
HPAB-0515LY Human Anti-NGF Recombinant Antibody (clone H26L17) ELISA Human IgG1
HPAB-0385-WJ Mouse Anti-NGF Recombinant Antibody (HPAB-0385-WJ) ELISA, FC, FuncS Mouse IgG
VS3-XY1165 Mouse Anti-NGF Recombinant Antibody (clone 1G4) WB, IP, IF Mouse IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-025ML Afuco™ Anti-NGF ADCC Recombinant Antibody (Frunevetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-031ML Afuco™ Anti-NGF ADCC Recombinant Antibody (Ranevetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-111 Afuco™ Anti-NGF ADCC Recombinant Antibody (Tanezumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-110 Afuco™ Anti-NGF Recombinant Antibody (AFC-TAB-110), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF Human IgG1, κ

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0718-FY-S(P) Mouse Anti-NGF Recombinant Antibody (clone AB020); Fab Fragment ELISA Mouse Fab
HPAB-0727-FY-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-0727-FY-S(P)) Inhib Human scFv
HPAB-0893-FY-S(P) Canine Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-0893-FY-S(P)) ELISA Canine scFv
HPAB-0894-FY-S(P) Canine Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-0894-FY-S(P)) ELISA Canine scFv
HPAB-0895-FY-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-0895-FY-S(P)) ELISA Humanized scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot

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