Rat Anti-NGF Recombinant Antibody (clone αD11) (CAT#: PABX-146-S (P))

Anti-NGF antibody is a Rat of scFv class that binds to an NGF. The rat monoclonal antibody (mAb) has been shown to bind to NGF with nanomolar affinity and with high specificity and to effectively neutralize its in vitro and in vivo biological functions.


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Figure 1 IP and WB of transgenic and wild-type mice.

Figure 1 IP and WB of transgenic and wild-type mice.

IP and WB of cortex extracts from male(M) and female(F) TgProNGF#72 and wild-type (WT) mice. IP on extracts from cortex(CTX) with anti-NGF aD11 antibody, followed by WB with anti-NGF or anti-proNGF antibody, as described in Tiveron et al.(2013). Are presentative WB probed with anti-proNGF(PAb Alomone),(top)or anti-NGFM20 (Santa Cruz)(bottom) is shown. TgproNGF#72 and wild type mice,male and female,were analyzed.

Malerba, F., Paoletti, F., & Cattaneo, A. (2016). NGF and proNGF reciprocal interference in immunoassays: open questions, criticalities, and ways forward. Frontiers in molecular neuroscience, 9, 63.

Figure 2 EmaxNGF Promega:NGFS tandard curves.

Figure 2 EmaxNGF Promega:NGFS tandard curves.

NGF standard curves carried out by usingr at mAb Promega(triangles) and mAb aD11(Cattaneoetal.,1988) (squares) as primary antibody.

Malerba, F., Paoletti, F., & Cattaneo, A. (2016). NGF and proNGF reciprocal interference in immunoassays: open questions, criticalities, and ways forward. Frontiers in molecular neuroscience, 9, 63.

Figure 3 SPR analysis-calibration curve sobtained with proNGF and NG Fover the panel of different antibodies.

Figure 3 SPR analysis-calibration curve sobtained with proNGF and NG Fover the panel of different antibodies.

Different pro NGF concentrations tested on anti-NGFmAb aD11. ConcentrationsinnM(fromtop): 500,333,222,148,98, 65,33,16,8,4,2,1,0.5.

Malerba, F., Paoletti, F., & Cattaneo, A. (2016). NGF and proNGF reciprocal interference in immunoassays: open questions, criticalities, and ways forward. Frontiers in molecular neuroscience, 9, 63.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Rat
  • Derivation
  • Rat
  • Type
  • Rat scFv
  • Species Reactivity
  • Human
  • Clone
  • αD11
  • Applications
  • Neut, FC, FuncS

Product Property

  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Target

  • Alternative Names
  • NGF; Beta-NGF; HSAN5; NGFB; PG110; ABT-110

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Humanized Antibody

Human Antibody

CAT Product Name Application Type
TAB-244 Anti-Human HNGF Recombinant Antibody Neut, ELISA, IF, IP, FuncS, FC, ICC IgG4 - kappa
TAB-488MZ Human Anti-NGF Recombinant Antibody (TAB-488MZ) ELISA Human IgG
TAB-489MZ Human Anti-NGF Recombinant Antibody (TAB-489MZ) ELISA, Neut Human IgG
TAB-512MZ Human Anti-NGF Recombinant Antibody (TAB-512MZ) ELISA, RIA, FC, SPR, Inhib Human IgG
TAB-513MZ Human Anti-NGF Recombinant Antibody (TAB-513MZ) ELISA, RIA, FC, SPR, Inhib Human IgG

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0852MZ Chicken Anti-NGF Polyclonal IgY ELISA Chicken antibody
BRD-1134MZ Chicken Anti-Beta NGF Polyclonal IgY ELISA, WB, IHC Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1768CQ Recombinant Mouse Anti-NGF Antibody (aD11) IF, BL, ELISA, IHC IgG1, κ
NEUT-1772CQ Recombinant Mouse Anti-NGF Antibody (25623.1) Dot, ELISA, Inhib IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2439 Hi-Affi™ Recombinant Rabbit Anti-NGF Monoclonal Antibody (DS2439AB) WB, ICC, IHC-P, IHC-P IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-025ML Afuco™ Anti-NGF ADCC Recombinant Antibody (Frunevetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-031ML Afuco™ Anti-NGF ADCC Recombinant Antibody (Ranevetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-111 Afuco™ Anti-NGF ADCC Recombinant Antibody (Tanezumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-110 Afuco™ Anti-NGF Recombinant Antibody (AFC-TAB-110), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF Human IgG1, κ

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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