Recombinant Anti-PREV Intrabody [Tat] (CAT#: IAB-B007(T))

• Immunogen
• porcine retroviruses

• Host Species
• llama

• Type
• vhh-Tat

• Cell Penetrating Peptide
• TAT
  TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.

• Species Reactivity
• PERV

• Applications
• Products can be used for: Protein fragment complementation; Neutralization; Functional studies

• Purity
• >95%, by SDS-PAGE, under reducing conditions

• Storage
• ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C

• Alternative Names
• PREV; porcine retroviruses

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