Anti-STEAP1 (vandortuzumab )-mc-val-cit-PABC-MMAE ADC (RG7450) (CAT#: ADC-L027)

• Antibody Overview
• Humanized IgG1 antibody vandortuzumab (Anti-STEAP1)

• Clone
• vandortuzumab

• Antibody Conjugation
• Humanized

• Linker
• mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.

• Alternative Names
• STEAP; PRSS24

• Gene ID
• 26872

• UniProt ID
• Q9UHE8

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