Mouse Anti-STEAP1 scFv-Fc Chimera (VS-0425-FY186)
CAT#: VS-0425-FY186
The anti-STEAP1 scFv-FC is a monoclonal antibody designed to target the STEAP1 protein. The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to STEAP1 with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of oncology and metabolism.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human lung
Immunohistochemical staining of human lung shows strong cytoplasmic and membranous positivity in pneumocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/123719_B_7_5.jpg
Normal Tissue
Figure 3 Prostate
Glandular cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/123719_A_3_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (ASC diff, CAPAN-2, U-138 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164647-STEAP1/subcellular
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Specifications
- Immunogen
- Purified human STEAP-1 as an immunogen.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human STEAP1
- Species Reactivity
- Human
- Applications
- ELISA, Western Blot, Immunohistochemistry, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500-1:5000
Immunohistochemistry: 1:50-1:500
ELISA: 1:100-1:10000
Flow Cytometry: 1-10 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- STEAP; PRSS24
- Gene ID
- 26872
- UniProt ID
- Q9UHE8
- Long Name
- STEAP Family Member 1
- Sequence Similarities
- Belongs to the STEAP family.
- Cellular Localization
- Endosome membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_036581.1
- Function
- Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH.
Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "STEAP1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0339 | APC-H-2Db/Human STEAP (VSKINRTEM) MHC Tetramer | FCM | |
| MHC-CN1233 | PE-A*02:01/Human STEAP1 (MLAVFLPIV) MHC Tetramer | FCM, IHC | |
| MHC-CN1234 | APC-A*02:01/Human STEAP1 (MLAVFLPIV) MHC Tetramer | FCM, IHC | |
| MHC-CN1235 | FITC-A*02:01/Human STEAP1 (MLAVFLPIV) MHC Tetramer | FCM, IHC | |
| MHC-CN1236 | A*02:01/Human STEAP1 (MLAVFLPIV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0259-YC-S(P) | Human Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-N0259-YC-S(P)) | FuncS | Humanized scFv |
| HPAB-0487-YJ-S(P) | Mouse Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-0487-YJ-S(P)) | FC, ELISA | Mouse scFv |
| HPAB-0488-YJ-S(P) | Mouse Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-0488-YJ-S(P)) | FC, ELISA | Mouse scFv |
| HPAB-0489-YJ-S(P) | Human Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-0489-YJ-S(P)) | FC, ELISA | Humanized scFv |
| HPAB-1208WJ-S(P) | Mouse Anti-STEAP1 Recombinant Antibody; scFv Fragment (HPAB-1208WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0259-YC-F(E) | Human Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-N0259-YC-F(E)) | FuncS | Humanized Fab |
| HPAB-0487-YJ-F(E) | Mouse Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-0487-YJ-F(E)) | FC, ELISA | Mouse Fab |
| HPAB-0488-YJ-F(E) | Human Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-0488-YJ-F(E)) | FC, ELISA | Fab |
| HPAB-0489-YJ-F(E) | Human Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-0489-YJ-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1208WJ-F(E) | Mouse Anti-STEAP1 Recombinant Antibody; Fab Fragment (HPAB-1208WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0487-YJ | Mouse Anti-STEAP1 Recombinant Antibody (HPAB-0487-YJ) | FC, ELISA | Mouse IgG1 |
| HPAB-0488-YJ | Human Anti-STEAP1 Recombinant Antibody (HPAB-0488-YJ) | FC, ELISA | Chimeric (mouse/human) IgG1 |
| HPAB-0489-YJ | Human Anti-STEAP1 Recombinant Antibody (HPAB-0489-YJ) | FC, ELISA | Humanized IgG1 |
| HPAB-1208WJ | Mouse Anti-STEAP1 Recombinant Antibody (HPAB-1208WJ) | FC, Inhib | Mouse IgG |
| PABS-0208 | Mouse Anti-STEAP1 Recombinant Antibody (PABS-0208) | ELISA, Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC524 | Recombinant Anti-STEAP1 Vesicular Antibody, EV Displayed (VS-0425-YC524) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6965 | Anti-STEAP1 Immunohistochemistry Kit | IHC |
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