Mouse Anti-STEAP1 scFv-Fc Chimera (VS-0425-FY186) (CAT#: VS-0425-FY186)
The anti-STEAP1 scFv-FC is a monoclonal antibody designed to target the STEAP1 protein. The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to STEAP1 with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of oncology and metabolism.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IHC staining of human lung
(Immunohistochemical staining of human lung shows strong cytoplasmic and membranous positivity in pneumocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/ihc_selected.jpg
(Immunohistochemical staining of human lung shows strong cytoplasmic and membranous positivity in pneumocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/ihc_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/123719_B_7_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/123719_B_7_5.jpg
Figure 3 Prostate
(Glandular cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/123719_A_3_5.jpg
(Glandular cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30985/123719_A_3_5.jpg
Figure 4 RNA cell line category: Cell line enhanced (ASC diff, CAPAN-2, U-138 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164647-STEAP1/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164647-STEAP1/subcellular
Specifications
- Immunogen
- Purified human STEAP-1 as an immunogen.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human STEAP1
- Species Reactivity
- Human
- Applications
- ELISA, Western Blot, Immunohistochemistry, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500-1:5000
Immunohistochemistry: 1:50-1:500
ELISA: 1:100-1:10000
Flow Cytometry: 1-10 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- STEAP; PRSS24
- Gene ID
- 26872
- UniProt ID
- Q9UHE8
- Long Name
- STEAP Family Member 1
- Sequence Similarities
- Belongs to the STEAP family.
- Cellular Localization
- Endosome membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_036581.1
- Function
- Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH.
Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1961CT | Recombinant Mouse anti-Human STEAP1 Monoclonal antibody (EML1413) | WB | |
| HPAB-0487-YJ | Mouse Anti-STEAP1 Recombinant Antibody (HPAB-0487-YJ) | FC, ELISA | Mouse IgG1 |
| HPAB-0488-YJ | Human Anti-STEAP1 Recombinant Antibody (HPAB-0488-YJ) | FC, ELISA | Chimeric (mouse/human) IgG1 |
| HPAB-0489-YJ | Human Anti-STEAP1 Recombinant Antibody (HPAB-0489-YJ) | FC, ELISA | Humanized IgG1 |
| HPAB-1208WJ | Mouse Anti-STEAP1 Recombinant Antibody (HPAB-1208WJ) | FC, Inhib | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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