Anti-TAL6 Antibody-Cytokine Fusion Protein, scFv (L6)-FasL
CAT#: ACFP-SH151
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAL6 scFv to FasL. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAL6 as well as the biological activity of FasL. This antibody-cytokine fusion protein is highly effective in in vitro killing of human TAG-72+ Jurkat-Ras tumor cells with a 500-fold greater cytotoxicity as compared to soluble FasL (sFasL). ScFv-FasLext with a strong cytotoxicity against sensitive human tumor targets may be useful as effective chemotherapeutic agents. This immunocytokine was designed for treating carcinomas of the breast, colon, lung, and ovary.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human fallopian tube
Immunohistochemical staining of human fallopian tube shows moderate membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_7_7_selected.jpg
Normal Tissue
Figure 2 IHC staining of human fallopian tube
Immunohistochemical staining of human fallopian tube shows strong cytoplasmic positivity with a granular pattern in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2760/7039_A_7_7_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_9_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (CAPAN-2, hTERT-RPE1, HUVEC TERT2, LHCN-M2, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169908-TM4SF1
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Specifications
- Target
- TAL6
- Molecule Class
- scFv-FasL
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- L6
- Related Disease
- Carcinomas of the breast, colon, lung, and ovary
- Cytokine 1
- FasL
- Cytokines 1 Description
- Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- TM4SF1; transmembrane 4 L six family member 1; L6; H-L6; M3S1; TAAL6; transmembrane 4 L6 family member 1; tumor-associated antigen L6; transmembrane 4 superfamily member 1; membrane component chromosome 3 surface marker 1; membrane component; chromosome 3; surface marker 1
- Gene ID
- 4071
- UniProt ID
- P30408
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COA
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- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| TAB-692CT | Mouse Anti-TM4SF1 Recombinant Antibody (TAB-692CT) | ELISA, FC, IHC | Mouse IgG |
| CAT | Product Name | Application | Type |
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| TAB-692CT-S(P) | Mouse Anti-TM4SF1 Recombinant Antibody; scFv Fragment (TAB-692CT-S(P)) | ELISA, FC, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0723-WK10 | Human Anti-TM4SF1 Recombinant Antibody (VS-0723-WK10) | FC | Human IgG1 |
| CAT | Product Name | Application | Type |
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| VS-0425-YC102 | Recombinant Anti-TM4SF1 Vesicular Antibody, EV Displayed (VS-0425-YC102) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY7317 | Anti-TM4SF1 Immunohistochemistry Kit | IHC |
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