Anti-TAL6 Antibody-Cytokine Fusion Protein, scFv (L6)-FasL (CAT#: ACFP-SH151)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAL6 scFv to FasL. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAL6 as well as the biological activity of FasL. This antibody-cytokine fusion protein is highly effective in in vitro killing of human TAG-72+ Jurkat-Ras tumor cells with a 500-fold greater cytotoxicity as compared to soluble FasL (sFasL). ScFv-FasLext with a strong cytotoxicity against sensitive human tumor targets may be useful as effective chemotherapeutic agents. This immunocytokine was designed for treating carcinomas of the breast, colon, lung, and ovary.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows moderate membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_7_7_selected.jpg
(Immunohistochemical staining of human fallopian tube shows moderate membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_7_7_selected.jpg
Figure 2 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2760/7039_A_7_7_selected.jpg
(Immunohistochemical staining of human fallopian tube shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2760/7039_A_7_7_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_B_7_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_B_7_5.jpg
Figure 4 Colon
(Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_9_3.jpg
(Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_9_3.jpg
Figure 5 RNA cell line category: Cell line enhanced (CAPAN-2, hTERT-RPE1, HUVEC TERT2, LHCN-M2, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169908-TM4SF1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169908-TM4SF1
Specifications
- Target
- TAL6
- Molecule Class
- scFv-FasL
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- L6
- Related Disease
- Carcinomas of the breast, colon, lung, and ovary
- Cytokine 1
- FasL
- Cytokines 1 Description
- Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- TM4SF1; transmembrane 4 L six family member 1; L6; H-L6; M3S1; TAAL6; transmembrane 4 L6 family member 1; tumor-associated antigen L6; transmembrane 4 superfamily member 1; membrane component chromosome 3 surface marker 1; membrane component; chromosome 3; surface marker 1
- Gene ID
- 4071
- UniProt ID
- P30408
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone L6"
See other products for "TM4SF1"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Mouse Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3551z | Mouse Anti-TM4SF1 Recombinant Antibody (clone 41H4) | FC, ICC, IHC | Mouse IgG1 |
| VS-0723-WK10 | Human Anti-TM4SF1 Recombinant Antibody (VS-0723-WK10) | FC | Human IgG1 |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for ACFP-SH151. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
![Figure 1 Anti-Human CD19 Recombinant Antibody Fab Fragment [TAB-1611CL-F(E)] in SDS-PAGE](https://img.creativebiolabs.net/productimages/COA-TAB-1611CL-F(E)-1.png)
Application: Depletion, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, WB
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
