Anti-TAL6 Antibody-Cytokine Fusion Protein, scFv (L6)-IL2 (CAT#: ACFP-SH050)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAL6 scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAL6 as well as the biological activity of IL2. Because interleukin-2 induces lymphocyte proliferation, fused antibody that targets interleukin-2 (IL-2) to a malignant or infected tissue can produce localized amplification of the immune response toward the diseased tissue, and thereby facilitate the destruction of the infected or malignant tissue. This immunocytokine was designed for treating carcinomas of the breast, colon, lung, and ovary.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows moderate membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_7_7_selected.jpg
(Immunohistochemical staining of human fallopian tube shows moderate membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_7_7_selected.jpg
Figure 2 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2760/7039_A_7_7_selected.jpg
(Immunohistochemical staining of human fallopian tube shows strong cytoplasmic positivity with a granular pattern in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2760/7039_A_7_7_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_B_7_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_B_7_5.jpg
Figure 4 Colon
(Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_9_3.jpg
(Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_9_3.jpg
Figure 5 RNA cell line category: Cell line enhanced (CAPAN-2, hTERT-RPE1, HUVEC TERT2, LHCN-M2, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169908-TM4SF1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169908-TM4SF1
Specifications
- Target
- TAL6
- Molecule Class
- scFv-IL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- L6
- Related Disease
- Carcinomas of the breast, colon, lung, and ovary
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- TM4SF1; transmembrane 4 L six family member 1; L6; H-L6; M3S1; TAAL6; transmembrane 4 L6 family member 1; tumor-associated antigen L6; transmembrane 4 superfamily member 1; membrane component chromosome 3 surface marker 1; membrane component; chromosome 3; surface marker 1
- Gene ID
- 4071
- UniProt ID
- P30408
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IgG Antibody Products
Mouse Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3551z | Mouse Anti-TM4SF1 Recombinant Antibody (clone 41H4) | FC, ICC, IHC | Mouse IgG1 |
| VS-0723-WK10 | Human Anti-TM4SF1 Recombinant Antibody (VS-0723-WK10) | FC | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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