Anti-TAL6 Antibody-Cytokine Fusion Protein, scFv (L6)-PF4
CAT#: ACFP-SH051
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAL6 scFv to PF4. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAL6 as well as the biological activity of PF4. The antibody-based fusion protein may be used to inhibit angiogenesis at a tumor site and thereby inhibit tumor growth. This immunocytokine was designed for treating carcinomas of the breast, colon, lung, and ovary.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human fallopian tube
Immunohistochemical staining of human fallopian tube shows moderate membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_7_7_selected.jpg
Normal Tissue
Figure 2 IHC staining of human fallopian tube
Immunohistochemical staining of human fallopian tube shows strong cytoplasmic positivity with a granular pattern in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2760/7039_A_7_7_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2823/8289_A_9_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (CAPAN-2, hTERT-RPE1, HUVEC TERT2, LHCN-M2, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169908-TM4SF1
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Specifications
- Target
- TAL6
- Molecule Class
- scFv-PF4
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- L6
- Related Disease
- Carcinomas of the breast, colon, lung, and ovary
- Cytokine 1
- PF4
- Cytokines 1 Description
- Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4). This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- TM4SF1; transmembrane 4 L six family member 1; L6; H-L6; M3S1; TAAL6; transmembrane 4 L6 family member 1; tumor-associated antigen L6; transmembrane 4 superfamily member 1; membrane component chromosome 3 surface marker 1; membrane component; chromosome 3; surface marker 1
- Gene ID
- 4071
- UniProt ID
- P30408
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone L6"
- CAT
- Product Name
See other products for "TM4SF1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3551z | Mouse Anti-TM4SF1 Recombinant Antibody (clone 41H4) | FC, ICC, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-692CT | Mouse Anti-TM4SF1 Recombinant Antibody (TAB-692CT) | ELISA, FC, IHC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-692CT-S(P) | Mouse Anti-TM4SF1 Recombinant Antibody; scFv Fragment (TAB-692CT-S(P)) | ELISA, FC, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-692CT-F(E) | Mouse Anti-TM4SF1 Recombinant Antibody; Fab Fragment (TAB-692CT-F(E)) | ELISA, FC, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0723-WK10 | Human Anti-TM4SF1 Recombinant Antibody (VS-0723-WK10) | FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC102 | Recombinant Anti-TM4SF1 Vesicular Antibody, EV Displayed (VS-0425-YC102) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7317 | Anti-TM4SF1 Immunohistochemistry Kit | IHC |
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