Recombinant Anti-human TBX21 Intrabody [Tat]
CAT#: IAB-B024(T)
Recombinant anti-TBX21 intrabody in fusion with HIV Tat works within cells to bind TBX21, expressed in E. coli cells. The antibody can down rugulate the Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG)
Gene Expression
Normal Tissue
Figure 1 Spleen
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9524/24853_B_7_4_val_selected.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30043/70685_A_8_4.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30043/70685_B_5_4.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30043/70685_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073861-TBX21
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Specifications
- Immunogen
- human T-box 21
- Host Species
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Antibody assay: Enzyme-linked Immunosorbent Assay; Neutralization; Functional studies
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at – 20 or -70°C upon receipt. Divide antibody into aliquots prior usage and avoid multiple freeze-thaw cycles.
Target
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TBX21"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3561z | Mouse Anti-TBX21 Recombinant Antibody (clone 29A4) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| MOB-1929CT | Recombinant Mouse anti-Human TBX21 Monoclonal antibody (39D) | ELISA, WB | |
| MRO-2210-CN | Rabbit Anti-Tbx21 Polyclonal Antibody (MRO-2210-CN) | WB, FC | Rabbit IgG |
| VS3-XY3520 | Rabbit Anti-TBX21 Recombinant Antibody (clone R07-7Y4) | IHC-P, FC | Rabbit IgG |
| VS13-YC1142 | Rabbit Anti-TBX21 Recombinant Antibody (VS13-YC1142) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B024(A) | Recombinant Anti-human TBX21 Intrabody [(D-Arg)9] | CO-IP, FuncS | scFv-(D-Arg)9 |
| IAB-B024(G) | Recombinant Anti-human TBX21 Intrabody [+36 GFP] | ELISA, IF, Neut, FuncS | scFv-(+36GFP) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3514 | Rabbit Anti-TBX21 Recombinant Antibody (clone DS3514AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7116 | Anti-TBX21 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7117 | Anti-Mouse TBX21 Immunohistochemistry Kit | IHC |
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