Afuco™ Anti-Human VEGFC ADCC Recombinant Antibody (VGX100), ADCC Enhanced
CAT#: AFC-635CL
Anti-VEGFC ADCC Enhanced Antibody (VGX100) is an ADCC enhanced antibody produced by our Afuco™ platform. VGX-100 is a human antibody that acts against the human vascular endothelial growth factor (VEGF)-C protein. Treatment for cancers, particularly glioblastoma and metastatic colorectal cancers, are the first target indications for VGX-100. Additionally, VGX-100 is developing for a number of other cancer indications, and as an agent to treat front-of the-eye diseases.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000150630-VEGFC
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- Neut, FuncS
- Related Disease
- Glioma; Prostate Cancer; Solid Tumors
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Applications
- Application Notes
- VEGF-C Neutralization with Blocking Antibody
VEGF-C was blocked using neutralizing monoclonal anti-VEGF-C (VGX-100). VGX-100 was commercially supplied, based on a signed material transfer agreement; and according to the manufacturer, VGX-100 binds to and precipitates all forms of VEGF-C including full-length, partially processed, and mature forms in both the human and mouse. To block VEGF-C, 20 mg/kg (in total 0.1 mL volume) of VGX-100 was injected from the day before surgery, through the intraperitoneal route and on alternate days subsequently up to 2 weeks. Control mice received 0.1 mL of normal saline intraperitoneally.
Target
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Robust immune response
I've used VGX100 in my oncology research, and the enhanced ADCC activity has significantly improved our results compared to traditional anti-VEGFC antibodies. The immune response is much more robust, which is critical for our therapeutic development.
Consistent potency and stability
We followed the recommended storage guidelines for VGX100 and observed consistent potency and stability over a six-month period. Proper storage is indeed crucial for maintaining its efficacy.
Better results with enhanced Fc region
The enhanced Fc region in VGX100 has made a noticeable difference in our efficacy studies. The level of immune cell engagement and subsequent tumor cell lysis was significantly higher compared to standard antibodies.
Q&As
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What specific laboratory assays can be used to verify the ADCC enhancement of Afuco™ Anti-Human VEGFC ADCC Recombinant Antibody (VGX100)?
A: ADCC enhancement for VGX100 can be verified through various assays such as the Chromium Release Assay, where target cells are labeled with chromium-51 and the lysis of these cells by effector cells in the presence of VGX100 is measured. Additionally, flow cytometry-based cytotoxicity assays and ELISA for cytokine release can also provide evidence of ADCC activity.
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How does this Antibody (VGX100) influence angiogenesis in tumor environments?
A: VGX100 targets VEGFC to inhibit its function, which is crucial for angiogenesis in tumor environments. By blocking VEGFC, VGX100 effectively reduces the formation of new blood vessels that supply nutrients and oxygen to the tumor, thereby inhibiting tumor growth and metastasis.
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How does the ADCC Enhanced antibody differ from traditional anti-VEGFC antibodies in terms of activation of the immune response?
A: Afuco™ Anti-Human VEGFC ADCC Recombinant Antibody (VGX100), ADCC Enhanced is specifically engineered for ADCC (Antibody-Dependent Cell-Mediated Cytotoxicity) enhancement. Unlike traditional anti-VEGFC antibodies, VGX100 not only neutralizes VEGFC but also optimizes the Fc region to more effectively engage immune effector cells, leading to an amplified and targeted immune response against VEGFC-expressing cells.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "VEGFC"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1722z | Mouse Anti-VEGFC Recombinant Antibody (clone 10F5) | WB, ICC, IF, IHC | Mouse IgG2a |
| MOB-0226MC | Anti-Human VEGF-C Antibody | WB, ICC, IF, IHC, IHC-P | |
| MOB-2183MZ | Recombinant Mouse Anti-Human VEGFC Antibody (clone 0/F8) | IHC-Fr, WB | Mouse antibody |
| VS3-QX1233 | Mouse Anti-VEGFC Recombinant Antibody (clone 2E2-F8-C6) | WB | |
| VS3-CJ994 | Mouse Anti-VEGFC Recombinant Antibody (VS3-CJ994) | WB | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-661CL | Human Anti-VEGFC Recombinant Antibody (TAB-661CL) | ELISA | Human IgG |
| TAB-311CQ | Human Anti-VEGFC Recombinant Antibody (TAB-311CQ) | ELISA, WB | Human IgG |
| TAB-311CQ-S(P) | Human Anti-VEGFC Recombinant Antibody (TAB-311CQ-S(P)); scFv Fragment | ELISA, WB, Neut | Human scFv |
| TAB-311CQ-F(E) | Human Anti-VEGFC Recombinant Antibody (TAB-311CQ-F(E)); Fab Fragment | ELISA, WB, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-309CQ | Human Anti-VEGFC Recombinant Antibody (TAB-309CQ) | Block, ELISA, FuncS | Humanized antibody |
| TAB-309CQ-S(P) | Human Anti-VEGFC Recombinant Antibody; scFv Fragment (TAB-309CQ-S(P)) | ELISA, FC, WB, BL | Humanized scFv |
| TAB-309CQ-F(E) | Human Anti-VEGFC Recombinant Antibody; Fab Fragment (TAB-309CQ-F(E)) | ELISA, FC, WB, BL | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-310CQ | Mouse Anti-VEGFC Recombinant Antibody (TAB-310CQ) | Block, ELISA, FuncS | Mouse IgG2a, κ |
| TAB-310CQ-S(P) | Mouse Anti-VEGFC Recombinant Antibody; scFv Fragment (TAB-310CQ-S(P)) | ELISA, FC, WB, BL | Mouse scFv |
| TAB-310CQ-F(E) | Mouse Anti-VEGFC Recombinant Antibody; Fab Fragment (TAB-310CQ-F(E)) | ELISA, FC, WB, BL | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2468 | Anti-VEGFC Immunohistochemistry Kit | IHC | |
| VS-0525-XY7842 | Anti-Mouse VEGFC Immunohistochemistry Kit | IHC | |
| VS-0525-XY7841 | Anti-Human VEGFC Immunohistochemistry Kit | IHC |
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