Anti-Lewis-Y (clone BR 96)-mc-Dox ADC
CAT#: ADC-005LZY
This ADC product is composed of an anti-Lewis-Y antibody (clone BR 96) conjugated via mc linker to Dox (BR 96-mc-Dox). It has demonstrated a response in Lewis-Y positive tumor treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase II and causing DNA damage.
Gene Expression
Normal Tissue
Figure 1 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46966/114457_A_6_6.jpg
Normal Tissue
Figure 2 Colon
Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Enterocytes - Microvilli Staining: Medium Intensity: Moderate Goblet cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46966/114457_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46966/114457_A_7_5.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46966/114457_B_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A-431, hTCEpi, OE19, RH-30, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171124-FUT3
❮
❯
Specifications
- Antibody Overview
- Chimeric anti Lewis-Y mAb,BR 96
- Clone
- BR 96
- Linker
- mc (maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- Doxorubicin
- Drug Class/Description
- Class: Doxorubicin
Description: Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.
Target
- Introduction
- The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
- Alternative Names
- FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); LE; Les; FT3B; CD174; FucT-III; galactoside 3(4)-L-fucosyltransferase; Lewis FT; fucosyltransferase III; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-fucosyltransferase;
- Gene ID
- 2525
- UniProt ID
- A8K737
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-005LZY. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "FUT3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1628z | Mouse Anti-FUT3 Recombinant Antibody (clone 5H6) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-0258CT | Recombinant Mouse anti-Human FUT3 Monoclonal antibody (3-36MF) | ELISA, ICC, IF, IHC-P, WB | |
| FAMAB-1370CQ | Human Anti-FUT3 Recombinant Antibody (clone PR 5C5) | ELISA, IF, IHC | Human IgG1 |
| VS2-QX87 | Mouse Anti-FUT3 Recombinant Antibody (clone MAL A) | Haemagglutination | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L017E | anti-FUT3 immunotoxin BR96 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L017R | anti-FUT3 immunotoxin BR96 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L055E | anti-FUT3 immunotoxin BR96 (scFv)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L055R | anti-FUT3 immunotoxin BR96 (scFv)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS2-QX25 | Mouse Anti-FUT3 Recombinant Antibody (clone BRIC 87) | ICC, IF, WB | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC703 | Recombinant Anti-FUT3 Vesicular Antibody, EV Displayed (VS-0425-YC703) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2673 | Anti-FUT3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2674 | Anti-Human FUT3 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: ELISA, WB, BLI, SPR
-YJ5.png)
Application: WB, ELISA, FC, IHC, IP
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, IHC, FC, IP, IF, FuncS
-3.jpg)
Application: Neut
Application: ELISA, WB, Microarray, Block
Application: FC
Application: ELISA, Cyt, PP, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
