anti-FUT3 immunotoxin BR96 (scFv)-RTA (AGTO-L055R)

This immunotoxin was achieved by conjugating/fusing the Anti-FUT3 scFv to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Vascular leak syndrome cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Vascular leak syndrome.      

Species Reactivity
Molecule Class
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Vascular leak syndrome
Alternative Names
FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); LE; Les; FT3B; CD174; FucT-III; galactoside 3(4)-L-fucosyltransferase

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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