Recombinant Anti-MET × Anti-EGFR Bispecific Antibody (Triplebody) (CAT#: TRIAB-MZ006)
This bispecific antibody shows remarkable increases in cell proliferation inhibitory effects, compared to the cases treated individually with the anti-c-Met antibody and the anti-EGFR antibody. ME22S induces dissociation of the Met-EGFR complex from Hsp90, followed by significant degradation of Met and EGFR. It is also capable of reducing the expression of both EGFR and Met and significantly inhibiting the cell migration, invasion, and proliferation of laryngeal cancer cells in vitro.
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Specifications
- Target
- MET & EGFR
- Type
- Triplebody
- Species Reactivity
- Human
- Target 1
- MET
- Host Species 1
- Human
- Target 2
- EGFR
- Host Species 2
- Human
- Application
- WB, ICC
- Related Disease
- Laryngeal cancer
Target
- Target 1
- MET
- Gene ID
- 4233
- UniProt ID
- A0A024R759
- Alternative Names
- MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
- Target 2
- EGFR
- Gene ID
- 1956
- UniProt ID
- P00533
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
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Tandem Diabody Products
Triplebody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAND-L008 | Recombinant Anti-MET × Anti-EGFR Bispecific Antibody (Tandem Diabody) | FuncS, Promising therapeutic agent | Tandem Diabody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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