Recombinant Mouse Anti-MET × Anti-EGFR Bispecific Antibody (Triplebody)
CAT#: TRIAB-MZ007
This bispecific antibody that specifically binds to human ErbB-1 and human c-Met comprises a first antigen-binding site that specifically binds to human ErbB-1 and a second antigen-binding site that specifically binds to human c-Met. It is capable of leading to a more pronounced inhibition of cancer cell proliferation and reducing the internalization of MET compared to the parent monospecific monovalent anti-c-Met antibody.
Specifications
- Target
- MET & EGFR
- Type
- Triplebody
- Species Reactivity
- Human
- Target 1
- MET
- Host Species 1
- Human
- Target 2
- EGFR
- Host Species 2
- Human
- Application
- FC
- Related Disease
- Human ovary carcinoma
Target
- Target 1
- MET
- Gene ID
- 4233
- UniProt ID
- A0A024R759
- Alternative Names
- MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
- Target 2
- EGFR
- Gene ID
- 1956
- UniProt ID
- P00533
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
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Overcomes EGFR Resistance
In our lung cancer cell lines that developed resistance to EGFR inhibitors, this bispecific antibody was able to restore growth inhibition. The dual targeting of MET and EGFR prevented the bypass signaling that usually causes resistance in our models.
Effective Receptor Degradation
Our western blot data showed that treatment with this bispecific antibody led to significant degradation of both MET and EGFR receptors. This mechanism of action is exactly what we were looking to study, and the reagent performed flawlessly.
Q&As
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How does this bispecific antibody address drug resistance in lung cancer?
A: Drug resistance in EGFR-mutant lung cancer often arises through the activation of the MET pathway as a bypass mechanism. This bispecific antibody targets both EGFR and MET simultaneously, blocking both primary and bypass signaling pathways, which helps to overcome resistance and inhibit tumor growth in research models.
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Does this antibody induce receptor degradation?
A: Yes, a key feature of this bispecific antibody is its ability to induce the internalization and degradation of both MET and EGFR receptors. This reduces the surface levels of these signaling proteins, providing a more durable inhibition of the downstream pathways compared to simple receptor blockade.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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See other products for "MET & EGFR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAND-L008 | Recombinant Anti-MET × Anti-EGFR Bispecific Antibody (Tandem Diabody) | FuncS, Promising therapeutic agent | Tandem Diabody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TRIAB-MZ006 | Recombinant Anti-MET × Anti-EGFR Bispecific Antibody (Triplebody) | WB, ICC | Triplebody |
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