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    MET & EGFR

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
    MET & EGFR
    Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.
    MET & EGFR
    Related Diseases
    Bladder Cancer Bladder Cancer
    EGFR Tyrosine Kinase Inhibitor Resistance EGFR Tyrosine Kinase Inhibitor Resistance
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Pancreatic Cancer Pancreatic Cancer
    Hepatocellular Carcinoma Hepatocellular Carcinoma
    Cushing Syndrome Cushing Syndrome
    Related Signaling Pathways
    JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
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