MET & EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
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- Targets: MET & EGFR
- Type: Tandem Diabody
- Application: FuncS, Promising therapeutic agent
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, WB, FuncS
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- Species Reactivity: Human
- Type: Human Fab
- Application: Block
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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- Species Reactivity: Human
- Type: Human scFv
- Application: Block
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Neut
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: Block
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB, FuncS
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Neut
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Human IgG
- Application: Block
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, WB, FuncS
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- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: FuncS, SPR
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, Neut
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- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: FuncS, ELISA, IF
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, Block, FuncS
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FuncS
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, Block, FuncS
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- Derivation: Human
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, Block, FuncS
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, FuncS
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- Species Reactivity: Human, Mouse, Rat
- Application: IHC, WB
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB, FuncS
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- Species Reactivity: Rat, Human
- Application: IHC, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, IF, IHC, FuncS
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- Derivation: Chimeric (Human/Mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Application: WB, FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Application: WB, IHC
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Derivation: Chimeric
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, WB
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG4 - kappa
- Application: FuncS, IF, Neut, ELISA, FC, IP, WB
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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- Derivation: Humanized (from rat)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG2 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
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- Species Reactivity: Mouse
- Type: Llama VHH
- Application: ELISA, IHC, FC, FuncS
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- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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- Derivation: Chimeric (human/mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, WB, Inhib
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, Inhib
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, Inhib
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Application: ELISA, FC, IF, FuncS
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) Fab
- Application: Block, Inhib, FuncS, Apop, In vivo
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Application: ELISA, FC, IF, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Human scFv
- Application: Block, Inhib, FuncS, Apop, In vivo
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- Application: ELISA, FC, IF, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Humanized Antibody
- Application: ELISA
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- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) IgG1
- Application: Block, Inhib, FuncS, Apop, In vivo
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- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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- Target: EGFR
- Linker: EDC/NHS
- Drug: MTX
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- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: TNFα
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: TNF-IgG2a
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Chimeric (Mouse-Human)
- Cytokine 1 Species: Human
- Molecule Class: IgG-IL2
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- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: MTX
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- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: IgG1-IL2
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- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IL2-IgG2a
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- Target: EGFR
- Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
- Drug: doxorubicin
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- Scaffold Name: Z-domain of protein A
- Target: EGFR
- Species Reactivity: Human
- Derivation: Phage display
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- Scaffold Name: 10-FnIII
- Target: EGFR
- Species Reactivity: Human
- Derivation: Phage display
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- Target: EGFR
- Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Drug: doxorubicin
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- Target: EGFR variant III
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Target: EGFR
- Linker: polyethylene glycol linker
- Drug: doxorubicin
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- Target: EGFRvIII
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Target: EGFR
- Linker: VC (valine-citrulline)
- Drug: Duostatin-3
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- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Target: EGFR
- Linker: Mal-dPEG4-NHS
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Target: epidermal growth factor receptor (EGFR)
- Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MODO (monomethyldolastatin)
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- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: MDC (maytansinol)
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Fab / Fc - G1 - kappa
- Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
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- Target: EGFR
- Linker: S-3AA
- Drug: MDC (maytansinol)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Target: EGFR
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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