Anti-LAMP1 (clone chMAb3)-N-succinimidyl-4-(6-pyridyldithio)butanoate (SPDB)-DM4 (N2-deacetyl-N2-(4-mercapto-4-methyl-5-oxopentyl) maytansine) ADC
CAT#: ADC-131CL
This ADC product is composed of an anti-LAMP1 antibody (clone chMAb3) conjugated via N-succinimidyl-4-(6-pyridyldithio)butanoate (SPDB) linker to DM4 (DM4-SPDB-chMAb3 VLR24-R93). It has demonstrated a response in cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.









Specifications
- Antibody Overview
- Anti-LAMP1 Antibody, chimer chMAb3_ VLR24-R93
- Clone
- chMAb3
- Linker
- SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
- Drug
- DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
- Alternative Names
- LAMP1; lysosomal-associated membrane protein 1; LAMPA; CD107a; LGP120; lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1;
- Gene ID
- 3916
- UniProt ID
- A0A024RDY3
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Datasheet
MSDS
COA
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CAT | Product Name | Application | Type |
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HPAB-0036-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0036-LSX-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
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HPAB-0038-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0038-LSX-F(E)) | ELISA, IHC | Human Fab |
HPAB-0039-LSX-F(E) | Human Anti-LAMP1 Recombinant Antibody; Fab Fragment (HPAB-0039-LSX-F(E)) | ELISA, IHC | Humanized Fab |
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