Anti-LAMP1 (clone huMAb1_2)-N-succinimidyl-4-(4-pyridyldithio)butanoate (SPDB)-DM4 (N2-deacetyl-N2-(4-mercapto-4-methyl-3-oxopentyl) maytansine) ADC (CAT#: ADC-129CL)

• Antibody Overview
• Anti-LAMP1 Antibody, Humanized huMAb1_2

• Clone
• huMAb1_2

• Linker
• SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)

• Drug
• DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

• Introduction
• The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

• Alternative Names
• LAMP1; lysosomal-associated membrane protein 1; LAMPA; CD107a; LGP120; lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1;

• Gene ID
• 3916

• UniProt ID
• A0A024RDY3

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