IL-13-DT immunotoxin (CAT#: AGTO-G040D)
This immunotoxin was achieved by conjugating/fusing the IL-13 to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of human solid tumors.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45831/1866_G1_31_selected.jpg
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45831/1866_G1_31_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67363/1754_D2_3_cr57f3cf6655f7f_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67363/1754_D2_3_cr57f3cf6655f7f_selected.jpg
Figure 3 RNA cell line category: Group enriched (PC-3, U-2197, U-251 MG, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000123496-IL13RA2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000123496-IL13RA2
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- IL-13-DT
- Toxin Description
- Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- human solid tumors
Target
- Alternative Names
- IL13RA2; interleukin 13 receptor, alpha 2; CT19; IL-13R; IL13BP; CD213A2; interleukin-13 receptor subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; cancer/testis antigen 19; IL-13 receptor subunit alpha-2; interleukin 13 binding protein; interleukin-13-binding protein; interleukin 13 receptor alpha 2 chain; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB420
- Gene ID
- 3598
- UniProt ID
- Q14627
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-555 | Recombinant Anti-human IL13RA2 Antibody | WB, Neut, FuncS | IgG |
| MHH-555 | Recombinant Human Anti-human IL13RA2 Antibody | ELISA, IP, FuncS | IgG |
| MOB-0783CT | Recombinant Mouse anti-Human IL13RA2 Monoclonal antibody (EML442) | FC, ICC/IF, IHC-Fr, IHC-P, IP, WB | |
| HPAB-0999WJ | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7) | ELISA, FC, IHC | Mouse IgG |
| HPAB-J0128-YC | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7) | ELISA, FC | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-555-F(E) | Recombinant Anti-human IL13RA2 Antibody Fab Fragment | IP, IF, FuncS | Fab |
| MHH-555-F(E) | Recombinant Human Anti-human IL13RA2 Antibody Fab Fragment | IP, IF, FuncS | Fab |
| HPAB-0999WJ-F(E) | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7); Fab Fragment | ELISA, FC, IHC | Mouse Fab |
| HPAB-J0128-YC-F(E) | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7); Fab Fragment | ELISA, FC | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-555-S(P) | Recombinant Anti-human IL13RA2 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| MHH-555-S(P) | Recombinant Human Anti-human IL13RA2 Antibody scFv Fragment | IF, FC, Biosensors, FuncS | scFv |
| HPAB-0999WJ-S(P) | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7); scFv Fragment | ELISA, FC, IHC | Mouse scFv |
| HPAB-J0128-YC-S(P) | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7); scFv Fragment | ELISA, FC | Mouse scFv |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G040E | IL-13-PE immunotoxin | Cytotoxicity assay, Function study |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0158CL | Human Anti-IL13RA2 Recombinant Antibody (TAB-0158CL) | ELISA, Internalization, BI, FuncS | Humanized IgG1, κ |
| TAB-0159CL | Human Anti-IL13RA2 Recombinant Antibody (TAB-0159CL) | ELISA, Internalization, BI, FuncS | Humanized IgG1, κ |
| TAB-0160CL | Human Anti-IL13RA2 Recombinant Antibody (TAB-0160CL) | ELISA, Internalization, BI, FuncS | Humanized IgG1, κ |
| TAB-0161CL | Human Anti-IL13RA2 Recombinant Antibody (TAB-0161CL) | ELISA, Internalization, BI, FuncS | Humanized IgG1, κ |
| TAB-0162CL | Human Anti-IL13RA2 Recombinant Antibody (TAB-0162CL) | ELISA, Internalization, BI, FuncS | Humanized IgG1, κ |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0154CL-F(E) | Mouse Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0154CL-F(E)) | ELISA, Internalization, BI, FuncS | Mouse Fab |
| TAB-0155CL-F(E) | Mouse Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0155CL-F(E)) | ELISA, Internalization, BI, FuncS | Mouse Fab |
| TAB-0156CL-F(E) | Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0156CL-F(E)) | ELISA, Internalization, BI, FuncS | Chimeric (mouse/human) Fab |
| TAB-0157CL-F(E) | Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0157CL-F(E)) | ELISA, Internalization, BI, FuncS | Chimeric (mouse/human) Fab |
| TAB-024ZJ-F(E) | Mouse Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-024ZJ-F(E)) | ELISA, WB, IP, IF, IHC, FC | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-383CQ | Human Anti-IL13RA2 Recombinant Antibody (TAB-383CQ) | ELISA | Human IgG |
| TAB-383CQ-S(P) | Human Anti-IL13RA2 Recombinant Antibody; scFv Fragment (TAB-383CQ-S(P)) | ELISA | Human scFv |
| TAB-383CQ-F(E) | Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-383CQ-F(E)) | ELISA | Human Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0279MZ | Chicken Anti-Interleukin-13 Receptor α2 Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1190CQ | Mouse Anti-IL13RA2 Recombinant Antibody (VMC188) | FC, ELISA, IHC, Block | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4241 | Rabbit Anti-IL13RA2 Recombinant Antibody (clone SI320DS) | ELISA | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0905 | PE-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer | FCM, IHC | |
| MHC-CN0906 | APC-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer | FCM, IHC | |
| MHC-CN0907 | FITC-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer | FCM, IHC | |
| MHC-CN0908 | A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer | FCM, IHC | |
| MHC-YF498 | A*02:01/Human IL13R (ALPFGFILV) MHC Pentamer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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