IL-13-PE immunotoxin

Name: IL-13-PE immunotoxin
SKU: AGTO-G040E
Rating: 5 (1 reviews)

CAT#: AGTO-G040E

This immunotoxin was achieved by conjugating/fusing the IL-13 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating human solid tumors.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45831/1866_G1_31_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67363/1754_D2_3_cr57f3cf6655f7f_selected.jpg

RNA Expression Figure 3 RNA cell line category: Group enriched (PC-3, U-2197, U-251 MG, U-87 MG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000123496-IL13RA2

❮

❯

Specifications

Host Species
Mouse

Species Reactivity
Human

Molecule Class
IL-13-PE

Toxin Description
Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.

Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.

Related Disease
human solid tumors

Target

Alternative Names
IL13RA2; interleukin 13 receptor, alpha 2; CT19; IL-13R; IL13BP; CD213A2; interleukin-13 receptor subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; cancer/testis antigen 19; IL-13 receptor subunit alpha-2; interleukin 13 binding protein; interleukin-13-binding protein; interleukin 13 receptor alpha 2 chain; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE66

Gene ID
3598

UniProt ID
Q14627

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for AGTO-G040E. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AGTO-G040E.pdf

MSDS

MSDS - AGTO-G040E.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "IL13RA2"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-555	Recombinant Anti-human IL13RA2 Antibody	WB, Neut, FuncS	IgG

CAT	Product Name	Application	Type
MOB-555-F(E)	Recombinant Anti-human IL13RA2 Antibody Fab Fragment	IP, IF, FuncS	Fab

CAT	Product Name	Application	Type
MOB-555-S(P)	Recombinant Anti-human IL13RA2 Antibody scFv Fragment	ELISA, WB, FuncS	scFv

CAT	Product Name	Application	Type
MHH-555	Recombinant Human Anti-human IL13RA2 Antibody	ELISA, IP, FuncS	IgG

CAT	Product Name	Application	Type
MHH-555-F(E)	Recombinant Human Anti-human IL13RA2 Antibody Fab Fragment	IP, IF, FuncS	Fab

CAT	Product Name	Application	Type
MHH-555-S(P)	Recombinant Human Anti-human IL13RA2 Antibody scFv Fragment	IF, FC, Biosensors, FuncS	scFv

CAT	Product Name	Application	Type
AGTO-G040D	IL-13-DT immunotoxin	Cytotoxicity assay, Function study

CAT	Product Name	Application	Type
TAB-0154CL	Mouse Anti-IL13RA2 Recombinant Antibody (TAB-0154CL)	ELISA, Internalization, BI, FuncS	Mouse IgG

CAT	Product Name	Application	Type
TAB-0155CL	Mouse Anti-IL13RA2 Recombinant Antibody (TAB-0155CL)	ELISA, Internalization, BI, FuncS	Mouse IgG

CAT	Product Name	Application	Type
TAB-0156CL	Human Anti-IL13RA2 Recombinant Antibody (TAB-0156CL)	ELISA, Internalization, BI, FuncS	Chimeric (mouse/human) IgG

CAT	Product Name	Application	Type
TAB-0157CL	Human Anti-IL13RA2 Recombinant Antibody (TAB-0157CL)	ELISA, Internalization, BI, FuncS	Chimeric (mouse/human) IgG

CAT	Product Name	Application	Type
TAB-0158CL	Human Anti-IL13RA2 Recombinant Antibody (TAB-0158CL)	ELISA, Internalization, BI, FuncS	Humanized IgG1, κ

CAT	Product Name	Application	Type
TAB-0159CL	Human Anti-IL13RA2 Recombinant Antibody (TAB-0159CL)	ELISA, Internalization, BI, FuncS	Humanized IgG1, κ

CAT	Product Name	Application	Type
TAB-0160CL	Human Anti-IL13RA2 Recombinant Antibody (TAB-0160CL)	ELISA, Internalization, BI, FuncS	Humanized IgG1, κ

CAT	Product Name	Application	Type
TAB-0161CL	Human Anti-IL13RA2 Recombinant Antibody (TAB-0161CL)	ELISA, Internalization, BI, FuncS	Humanized IgG1, κ

CAT	Product Name	Application	Type
TAB-0162CL	Human Anti-IL13RA2 Recombinant Antibody (TAB-0162CL)	ELISA, Internalization, BI, FuncS	Humanized IgG1, κ

CAT	Product Name	Application	Type
TAB-0154CL-S(P)	Mouse Anti-IL13RA2 Recombinant Antibody; scFv Fragment (TAB-0154CL-S(P))	ELISA, Internalization, BI, FuncS	Mouse scFv

CAT	Product Name	Application	Type
TAB-025ZJ	Mouse Anti-IL13RA2 Recombinant Antibody (TAB-025ZJ)	ELISA, WB, IP, IF, IHC, FC	Mouse IgM, κ

CAT	Product Name	Application	Type
TAB-383CQ	Human Anti-IL13RA2 Recombinant Antibody (TAB-383CQ)	ELISA	Human IgG

CAT	Product Name	Application	Type
TAB-383CQ-S(P)	Human Anti-IL13RA2 Recombinant Antibody; scFv Fragment (TAB-383CQ-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-383CQ-F(E)	Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-383CQ-F(E))	ELISA	Human Fab

CAT	Product Name	Application	Type
MOB-0783CT	Recombinant Mouse anti-Human IL13RA2 Monoclonal antibody (EML442)	FC, ICC, IF, IHC-Fr, IHC-P, IP, WB

CAT	Product Name	Application	Type
BRD-0279MZ	Chicken Anti-Interleukin-13 Receptor α2 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-1190CQ	Mouse Anti-IL13RA2 Recombinant Antibody (VMC188)	FC, ELISA, IHC, Block	Mouse IgG1, κ

CAT	Product Name	Application	Type
MOR-4241	Rabbit Anti-IL13RA2 Recombinant Antibody (clone SI320DS)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
MHC-CN0905	PE-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer	FCM, IHC

CAT	Product Name	Application	Type
MHC-CN0906	APC-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer	FCM, IHC

CAT	Product Name	Application	Type
MHC-CN0907	FITC-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer	FCM, IHC

CAT	Product Name	Application	Type
MHC-CN0908	A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer	FCM, IHC

CAT	Product Name	Application	Type
HPAB-0999WJ	Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7)	ELISA, FC, IHC	Mouse IgG

CAT	Product Name	Application	Type
HPAB-0999WJ-S(P)	Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7); scFv Fragment	ELISA, FC, IHC	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0999WJ-F(E)	Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7); Fab Fragment	ELISA, FC, IHC	Mouse Fab

CAT	Product Name	Application	Type
HPAB-J0128-YC	Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7)	ELISA, FC	Mouse IgG

CAT	Product Name	Application	Type
HPAB-J0128-YC-S(P)	Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7); scFv Fragment	ELISA, FC	Mouse scFv

CAT	Product Name	Application	Type
HPAB-J0128-YC-F(E)	Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7); Fab Fragment	ELISA, FC	Mouse Fab

CAT	Product Name	Application	Type
VS-0325-FY108	Mouse Anti-IL13RA2 (clone 2-7) scFv-Fc Chimera	ELISA, FC, IHC	Mouse IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC351	Recombinant Anti-IL13RA2 Vesicular Antibody, EV Displayed (VS-0425-YC351)	ELISA, FC, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY3486	Anti-IL13RA2 Immunohistochemistry Kit	IHC

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Formats:

Isotype Switching:

Fc Engineering:

Modalities:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Anti-Human CD22 Recombinant Antibody (TAB-176) (CAT# TAB-176)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Human Anti-ERBB3 Recombinant Antibody (TAB-189) (CAT# TAB-189)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Anti-Human Nogo-A Recombinant Antibody (TAB-903) (CAT# TAB-903)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Anti-Human EGFR Recombinant Antibody (TAB-119) (CAT# TAB-119)
Application: FC, IP, ELISA, Neut, FuncS, IF, WB

Anti-Human CD2 Recombinant Antibody (TAB-104) (CAT# TAB-104)
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC

Anti-Human CD3E Recombinant Antibody (TAB-159) (CAT# TAB-159)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Anti-ERBB2 Recombinant Antibody (Margetuximab) (CAT# TAB-761)
Application: IF, IP, Neut, FuncS, ELISA, FC, WB

Anti-Human ERBB3/ErbB 3 Recombinant Antibody (Seribantumab) (CAT# TAB-892)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Anti-Human ERBB2 Recombinant Antibody (TAB-053) (CAT# TAB-053)
Application: FuncS, IF, Neut, ELISA, FC, IP, WB

Anti-Human CD40 Recombinant Antibody (TAB-152) (CAT# TAB-152)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Anti-Human VEGF Recombinant Antibody Fab Fragment (TAB-012-F(E)) (CAT# TAB-012-F(E))
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC

Human Anti-Human CD27 Recombinant Antibody (TAB-H74) (CAT# TAB-H74)
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC

Recombinant Mouse Anti-AAV 2 Antibody (CAT# MHH-19)
Application: IF, Neut, FuncS

Recombinant Human Anti-HRV-C Antibody (CAT# MHH-513)
Application: WB, Neut, FuncS

Anti-Human DKK1 Recombinant Antibody (BHQ880) (CAT# TAB-214CL)
Application: IHC, ELISA, IB

Anti-Human MET Recombinant Antibody (TAB-521CL) (CAT# TAB-521CL)
Application: WB, FuncS

Mouse Anti-PF4 Recombinant Antibody (clone KKO) (CAT# PABL-299)
Application: ELISA, FuncS

Mouse Anti-EGFR Recombinant Antibody (clone 7A7) (CAT# PABW-088)
Application: ELISA, WB

Recombinant Mouse Anti-HCV E2 Antibody (AP33) (CAT# PABL-496)
Application: FC, Neut, FuncS

Mouse Anti-α4β7 Recombinant Antibody (PABL-746) (CAT# PABL-746)
Application: FC

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.