IP10-DT immunotoxin
CAT#: AGTO-L073D
This immunotoxin was achieved by conjugating/fusing the IP10 to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Th1 cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of Autoimmune diseases.
Gene Expression
Normal Tissue
Figure 1 Colon
Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45942/139633_A_8_3.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45942/139633_A_7_4.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45942/139633_A_5_6.jpg
Normal Tissue
Figure 4 High expression in lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45942/139633_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186810-CXCR3
❮
❯
Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- IP10-DT
- Toxin Description
- Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Autoimmune diseases
Target
- Alternative Names
- C-X-C chemokine receptor type 3; CD 183; CD182; CD183; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; Chemokine CXC Motif Receptor 3; CKR L2; CKR-L2; CKRL2; CMKAR3; CXC-R3; CXCR-3; CXCR3; CXCR3_HUMAN; G Protein Coupled Receptor 9; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP-10 receptor; IP10; IP10 R; IP10 receptor; IP10-R; IP10R; Mig R; Mig receptor; Mig-R; MIGR; Autoimmune diseases; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389
- Gene ID
- 2833
- UniProt ID
- P49682
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for AGTO-L073D. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CXCR3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-135MZ | Human Anti-CXCR3 Recombinant Antibody (TAB-135MZ) | FuncS | Human IgG2, κ |
| TAB-125MZ-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-125MZ-F(E)) | FC | Human Fab |
| TAB-126MZ-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-126MZ-F(E)) | FC | Human Fab |
| TAB-134MZ-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-134MZ-F(E)) | Chemotaxis assay | Human Fab |
| TAB-135MZ-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-135MZ-F(E)) | Chemotaxis assay | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-127MZ-F(E) | Mouse Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-127MZ-F(E)) | FC | Mouse Fab |
| TAB-129MZ-F(E) | Mouse Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-129MZ-F(E)) | FC | Mouse Fab |
| TAB-130MZ-F(E) | Mouse Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-130MZ-F(E)) | FC | Mouse Fab |
| TAB-131MZ-F(E) | Mouse Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-131MZ-F(E)) | FC | Mouse Fab |
| TAB-132MZ-F(E) | Mouse Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-132MZ-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-128MZ-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (TAB-128MZ-F(E)) | FC | Humanized Fab |
| TAB-136MZ-F(E) | Anti-Human CXCR3 Recombinant Antibody Fab Fragment (Ab1) | FC, Binding and chemotaxis assay | Humanized antibody |
| TAB-137MZ-F(E) | Anti-Human CXCR3 Recombinant Antibody Fab Fragment (Ab2) | FC, Binding and chemotaxis assay | Humanized antibody |
| TAB-138MZ-F(E) | Anti-Human CXCR3 Recombinant Antibody Fab Fragment (Ab3) | FC, Binding and chemotaxis assay | Humanized antibody |
| TAB-139MZ-F(E) | Anti-Human CXCR3 Recombinant Antibody Fab Fragment (Ab4) | FC, Binding and chemotaxis assay | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2068MZ | Recombinant Mouse Anti-Human CXCR3 Antibody (clone 3Bs2) | FC, ICC, IF, IHC-Fr, IHC-P, Neut | Mouse antibody |
| HPAB-0378-YC | Mouse Anti-CXCR3 Recombinant Antibody (HPAB-0378-YC) | FC | Mouse IgG |
| HPAB-0379-YC | Mouse Anti-CXCR3 Recombinant Antibody (HPAB-0379-YC) | ELISA, FC, FuncS | Mouse IgG |
| HPAB-0380-YC | Mouse Anti-CXCR3 Recombinant Antibody (HPAB-0380-YC) | ELISA, FC, FuncS | Mouse IgG |
| HPAB-N0344-YC | Human Anti-CXCR3 Recombinant Antibody (53hu37) | FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-678CQ | Mouse Anti-CXCR3 Recombinant Antibody (clone G025H7) | FC, Block | Mouse IgG1, κ |
| NEUT-683CQ | Hamster Anti-Cxcr3 Recombinant Antibody (clone CXCR3-173) | FC, Block | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-679CQ | Mouse Anti-CXCR3 Recombinant Antibody (clone 2Ar1) | ICC, IF, IHC-P, IHC-Fr, Neut, FC | Mouse IgG1 |
| NEUT-680CQ | Mouse Anti-CXCR3 Recombinant Antibody (clone CBL045) | FC, IHC, Neut | Mouse IgG1 |
| NEUT-681CQ | Mouse Anti-CXCR3 Recombinant Antibody (clone CBL794) | FC, IHC, CyTOF®, Neut | Mouse IgG1 |
| NEUT-682CQ | Mouse Anti-CXCR3 Recombinant Antibody (clone MM0223-7K22) | IHC-Fr, Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0888 | Hi-Affi™ Rabbit Anti-CXCR3 Recombinant Antibody (clone DS888AB) | WB, ICC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0378-YC-S(P) | Mouse Anti-CXCR3 Recombinant Antibody; scFv Fragment (HPAB-0378-YC-S(P)) | FC | Mouse scFv |
| HPAB-0379-YC-S(P) | Mouse Anti-CXCR3 Recombinant Antibody; scFv Fragment (HPAB-0379-YC-S(P)) | ELISA, FC, FuncS | Mouse scFv |
| HPAB-0380-YC-S(P) | Mouse Anti-CXCR3 Recombinant Antibody; scFv Fragment (HPAB-0380-YC-S(P)) | ELISA, FC, FuncS | Mouse scFv |
| HPAB-N0344-YC-S(P) | Human Anti-CXCR3 Recombinant Antibody; scFv Fragment (53hu37) | FuncS | Humanized scFv |
| HPAB-AP312-YC-S(P) | Mouse Anti-CXCR3 Recombinant Antibody; scFv Fragment (HPAB-AP312-YC-S(P)) | FC, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP312-YC-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (HPAB-AP312-YC-F(E)) | FC, Inhib | Chimeric (mouse/human) Fab |
| HPAB-AP313-YC-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (HPAB-AP313-YC-F(E)) | FC, Inhib | Humanized Fab |
| HPAB-AP314-YC-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (HPAB-AP314-YC-F(E)) | FC, Inhib | Humanized Fab |
| HPAB-AP315-YC-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (HPAB-AP315-YC-F(E)) | FC, Inhib | Chimeric (mouse/human) Fab |
| HPAB-AP316-YC-F(E) | Human Anti-CXCR3 Recombinant Antibody; Fab Fragment (HPAB-AP316-YC-F(E)) | FC, Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC277 | CytoStream™ Mouse Anti-CXCR3 Recombinant Antibody (VS13-YC277) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC497 | Recombinant Anti-CXCR3 Vesicular Antibody, EV Displayed (VS-0425-YC497) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1824 | Anti-CXCR3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC38 | Recombinant Anti-CXCR3 (AA 1-15 x AA 16-30) Biparatopic Antibody, Tandem scFv (Clone 1C6 x Clone 4B4) | ELISA, FC | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: WB, ELISA, FC, IHC, IP
Application: Neut, FC, IHC-Fr, IP, BA
Application: ELISA, Inhib, FC, Neut
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
