PDZ domain scaffold protein anti-Human NMDA receptor NR2 subunits (CAT#: SPD-L169)
The PDZ domain that bound NMDA receptor NR2 subunits was isolated from the library using Yeast Two-hybrid techonology. PDZ domains are modular protein-interaction domains that are specialized for binding to short peptide motifs at the extreme carboxy (C) termini of other proteins, athough they can also have other modes of interaction. After affinity maturation, PDZ domain variants were identified having affinities for NMDA receptor NR2 subunits as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in cerebral cortex.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_B_9_5_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_B_9_5_selected.jpg
Figure 2 Low expression in kidney.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_A_8_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_A_8_5_val_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_B_9_5.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_B_9_5.jpg
Figure 4 Cerebellum
(Bergmann glia - cytoplasm/membrane Staining: Not detected Intensity: Negative Bergmann glia - nucleus Staining: Not detected Intensity: Negative GLUC cells - cytoplasm/membrane Staining: Not detected Intensity: Negative GLUC cells - nucleus Staining: Not detected Intensity: Negative Granular cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Granular cells - nucleus Staining: Not detected Intensity: Negative Molecular layer - neuropil Staining: Not detected Intensity: Negative Molecular layer cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Molecular layer cells - nucleus Staining: Not detected Intensity: Negative Processes in granular layer Staining: Not detected Intensity: Negative Processes in molecular layer Staining: Not detected Intensity: Negative Processes in white matter Staining: Not detected Intensity: Negative Purkinje cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Purkinje cells - dendrites Staining: Not detected Intensity: Negative Purkinje cells - nucleus Staining: Not detected Intensity: Negative Synaptic glomeruli - capsule Staining: Not detected Intensity: Negative Synaptic glomeruli - core Staining: High Intensity: Strong White matter cells - cytoplasm/membrane Staining: Not detected Intensity: Negative White matter cells - nucleus Staining: Not detected Intensity: Negative)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_B_7_8.jpg
(Bergmann glia - cytoplasm/membrane Staining: Not detected Intensity: Negative Bergmann glia - nucleus Staining: Not detected Intensity: Negative GLUC cells - cytoplasm/membrane Staining: Not detected Intensity: Negative GLUC cells - nucleus Staining: Not detected Intensity: Negative Granular cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Granular cells - nucleus Staining: Not detected Intensity: Negative Molecular layer - neuropil Staining: Not detected Intensity: Negative Molecular layer cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Molecular layer cells - nucleus Staining: Not detected Intensity: Negative Processes in granular layer Staining: Not detected Intensity: Negative Processes in molecular layer Staining: Not detected Intensity: Negative Processes in white matter Staining: Not detected Intensity: Negative Purkinje cells - cytoplasm/membrane Staining: Not detected Intensity: Negative Purkinje cells - dendrites Staining: Not detected Intensity: Negative Purkinje cells - nucleus Staining: Not detected Intensity: Negative Synaptic glomeruli - capsule Staining: Not detected Intensity: Negative Synaptic glomeruli - core Staining: High Intensity: Strong White matter cells - cytoplasm/membrane Staining: Not detected Intensity: Negative White matter cells - nucleus Staining: Not detected Intensity: Negative)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/22725/151907_B_7_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, hTERT-RPE1, RPMI-8226, U-138 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000183454-GRIN2A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000183454-GRIN2A
Specifications
- Scaffold Name
- PDZ domain
- Origin
- PSD-95 protein
- Core Structure
- β-sheet
- Target
- NMDA receptor NR2 subunits
- Species Reactivity
- Human
- Expression Host
- E. coli
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- PSD-95 protein; PDZ domain; LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A
- Gene ID
- 2903
- UniProt ID
- Q12879
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