PE-A*02:01/Human IRS1 (GLENGLNYI) MHC Tetramer
CAT#: MHC-LC4426
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human IRS1 of peptide GLENGLNYI covering 1172-1180 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46433/824_C8_5_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5261/963_D12_1_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5261/19658_B_9_5.jpg
Normal Tissue
Figure 4 Cerebellum
Cells in granular layer Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5261/19658_B_9_8.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5261/19658_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5261/19658_A_7_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169047-IRS1
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Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- IRS1
- Antigen Species
- Human
- Peptide
- GLENGLNYI
- Range
- 1172-1180
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
- Alternative Names
- IRS1; Insulin receptor substrate 1; HIRS-1
- Gene ID
- 3667
- UniProt ID
- P35568
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Related Signaling Pathways
Insulin Signaling Pathway
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway
PPAR Signaling Pathway
Related Diseases
Insulin Resistance
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "IRS1"
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|---|---|---|---|
| MOB-2476z | Mouse Anti-IRS1 Recombinant Antibody (clone 36A2) | WB, FC, IHC | Mouse IgG2a |
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| FAMAB-1375CQ | Mouse Anti-IRS1 Recombinant Antibody (clone IRS 8-63) | IB, IP, WB | Mouse IgG1 |
| VS3-CJ905 | Rabbit Anti-IRS1 Recombinant Antibody (VS3-CJ905) | WB, ICC, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1540CQ | Recombinant Mouse Anti-IRS1 Antibody (CBL216) | Inhib | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1861 | Hi-Affi™ Recombinant Rabbit Anti-IRS1 Monoclonal Antibody (DS1861AB) | WB | IgG |
| MOR-4635 | Hi-Affi™ Recombinant Rabbit Anti-IRS1 Monoclonal Antibody (TH148DS) | WB, IHC-P | IgG |
| MOR-4689 | Hi-Affi™ Recombinant Rabbit Anti-IRS1 Monoclonal Antibody (TH203DS) | WB, IF, ICC, FC | IgG |
| MOR-0045-FY | Rabbit Anti-IRS1 Recombinant Antibody (clone AFY0016) | IHC, WB, Inhib | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY286 | Mouse Anti-NHP IRS1 Recombinant Antibody (VS-1024-XY286) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3599 | Anti-IRS1 Immunohistochemistry Kit | IHC |
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