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IRS1
Loading...Anti-IRS1 Products
- Recombinant Mouse Anti-IRS1 Antibody (CBL216) (NEUT-1540CQ)
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- Species Reactivity: Human, Bovine, Porcine, Sheep
- Type: IgG1
- Application: Inhib
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- Mouse Anti-IRS1 Recombinant Antibody (FAMAB-1375CQ) (FAMAB-1375CQ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: IB, IP, WB
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- Mouse Anti-IRS1 Antibody, mRNA (FAMAB-1375CQ-mRNA) (FAMAB-1375CQ-mRNA)
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- Species Reactivity: Human, Mouse, Rat
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- PE-A*02:01/Human IRS1 (GLENGLNYI) MHC Tetramer (MHC-LC4426)
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- Class: Class I
- Antigen: IRS1
- Antigen Species: Human
- Peptide: GLENGLNYI
- Conjugate: PE
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- Mouse Anti-NHP IRS1 Recombinant Antibody (VS-1024-XY286) (VS-1024-XY286)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB
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- Anti-IRS1 Immunohistochemistry Kit (VS-0525-XY3599)
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- Species Reactivity: Human
- Target: IRS1
- Application: IHC
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- Anti-IRS1 Antibody Prodrug, Protease Activated (IRS 8-63) (VS-1025-YC209)
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- Species Reactivity: Human, Mouse, Rat
- Host Animal: Mouse
- Target: IRS1
- Application: ISZ, Cyt, FuncS
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Rabbit Anti-IRS1 Recombinant Antibody (clone AFY0016) (MOR-0045-FY)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IHC, WB, Inhib
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
Protein class
Disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Theca cells, Granulosa cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Interacts with UBTF and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 and FER (By similarity). Interacts (via PH domain) with PHIP (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7 (PubMed:16127460). Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif) (PubMed:7541045, PubMed:7559478, PubMed:7537849). Interacts with ALK (PubMed:15226403, PubMed:16878150). Interacts with EIF2AK2/PKR (By similarity). Interacts with GKAP1 (By similarity). Interacts with DGKZ in the absence of insulin; insulin stimulation decreases this interaction (By similarity). Found in a ternary complex with DGKZ and PIP5K1A in the absence of insulin stimulation (By similarity).
Molecular function
Transducer
More Types Infomation
Related Signaling Pathways
Insulin Signaling Pathway
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway
PPAR Signaling Pathway
Related Diseases
Insulin Resistance
