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PE-DRB1*04:04/Human HLA-DRA (ANIAVDKANLEIMTKR) MHC Tetramer (CAT#: MHC-LC3350)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HLA-DRA of peptide ANIAVDKANLEIMTKR covering 86-101 and DRB1*04:04 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.


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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 Cerebral cortex
Figure 1 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_B_8_5.jpg
Figure 2 Colon
Figure 2 Colon
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_8_3.jpg
Figure 3 High expression in lymph node
Figure 3 High expression in lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_7_8.jpg
Figure 4 Tonsil
Figure 4 Tonsil
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_5_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-266/70, U-698, U-87 MG)
Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-266/70, U-698, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204287-HLA-DRA

Specifications

  • Allele
  • DRB1*04:04
  • Class
  • Class II
  • Antigen
  • HLA-DRA
  • Antigen Species
  • Human
  • Peptide
  • ANIAVDKANLEIMTKR
  • Range
  • 86-101
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain precursor; HLA-DRA1

Downloads

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MHC Tetramer for Other Applications

CAT Product Name Application Type
MHC-LC703 I-Ab/Human Eα (ASFEAQGALANIAVDKA) MHC Tetramer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1622 Rabbit Anti-HLA-DRA Recombinant Antibody (clone DS1622AB) ICC, IHC-P, IP, WB Rabbit IgG

Neuroscience Antibody

CAT Product Name Application Type
NS-037CN Human Anti-HLA-DRA Recombinant Antibody (clone HD4) ELISA, WB, FC, FuncS Human IgG1
NS-038CN Human Anti-HLA-DRA Recombinant Antibody (clone HD8) ELISA, WB, FC, FuncS Human IgG2
NS-037CN-F(E) Human Anti-HLA-DRA Recombinant Antibody (clone HD4); Fab Fragment ELISA, WB, FC Human Fab
NS-038CN-F(E) Human Anti-HLA-DRA Recombinant Antibody (clone HD8); Fab Fragment ELISA, WB, FC Human Fab
NS-037CN-S(P) Human Anti-HLA-DRA Recombinant Antibody (clone HD4); scFv Fragment ELISA, WB, FC Human scFv

Recombinant Antibody

CAT Product Name Application Type
MRO-1936-CN Rabbit Anti-HLA-DRA Polyclonal Antibody (MRO-1936-CN) WB, IF, IHC, FC Rabbit IgG
MRO-1937-CN Rabbit Anti-HLA-DRA Polyclonal Antibody (MRO-1937-CN) WB, IF, IHC, FC Rabbit IgG
ZG-1015F Mouse Anti-HLA-DRA Recombinant Antibody (clone Bra30) FC, ICC, IHC-Fr, IP, WB Mouse IgG2a
VS3-WK1317 Mouse Anti-HLA-DRA Recombinant Antibody (VS3-WK1317) ELISA, WB Mouse IgG1
VS3-WK1504 Mouse Anti-HLA-DRA Recombinant Antibody (clone 4ALN3) FC, IF Mouse IgG2b

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0025-YJ-S(P) Mouse Anti-HLA-DRA Recombinant Antibody (clone ChDN1924); scFv Fragment Apop, IF Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0025-YJ-F(E) Human Anti-HLA-DRA Recombinant Antibody (clone ChDN1924); Fab Fragment Apop, IF Chimeric (mouse/human) Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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