Human Anti-HLA-DRA Recombinant Antibody (clone ChDN1924); Fab Fragment (CAT#: HPAB-0025-YJ-F(E))
This product is a recombinant chimeric (human/mouse) Fab that recognizes the first HLA-DR domains. Chimeric DN1924 is effective in inducing apoptosis in HLA-DR-expressing tumor cells, but not in HLA-DR-negative tumor cells or in normal HLA-DR-expressing cells. It has the potential to reduce the rate of tumor growth and promote increased survival.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_B_8_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_B_8_5.jpg
Figure 2 Colon
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_8_3.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_8_3.jpg
Figure 3 High expression in lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_7_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_7_8.jpg
Figure 4 Tonsil
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_5_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53176/125541_A_5_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-266/70, U-698, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204287-HLA-DRA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204287-HLA-DRA
Specifications
- Immunogen
- BALB/c-derived mutant B lymphoma line M12.C3, transfected with chimeric human/mouse class II gene was used as the immunogen.
- Host Species
- Human
- Type
- Chimeric (mouse/human) Fab
- Specificity
- Human HLA-DRA
- Species Reactivity
- Human
- Clone
- ChDN1924
- Applications
- Apop, IF
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Major Histocompatibility Complex, Class II, DR Alpha; MHC Class II Antigen DRA; HLA-DRA1; HLA Class II Histocompatibility Antigen, DR Alpha Chain; Histocompatibility Antigen HLA-DR Alpha; Chimeric DN-1924; Chimeric DN1924
- Gene ID
- 3122
- UniProt ID
- P01903
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2072z | Mouse Anti-HLA-DRA Recombinant Antibody (clone 16F11) | WB, ELISA, FC, ICC, IHC | Mouse IgG2b |
| VS3-WK1317 | Mouse Anti-HLA-DRA Recombinant Antibody (VS3-WK1317) | ELISA, WB | Mouse IgG1 |
| VS-0724-XY76 | Human Anti-HLA-DRA Recombinant Antibody (clone c44H10) | ELISA, BLI | Human IgG |
| VS-0724-XY78 | Monkey Anti-HLA-DRA Recombinant Antibody (clone MS-GPC-8-10-57) | ELISA, BLI, Neut | Monkey IgG4 |
| VS-0724-XY77 | Mouse Anti-HLA-DRA Recombinant Antibody (clone K8-355) | ELISA, FC | Mouse IgG1 kappa |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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