PE-HLA-A2/Human WT1 (YMFPNAPYL) MHC Tetramer
CAT#: MHC-LC1571
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of WT1-derived peptide of YMFPNAPYL covering 126-134 and HLA-A2 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- HLA-A2
- Class
- Class I
- MHC Species
- Human
- Antigen
- WT1
- Antigen Species
- Human
- Peptide
- YMFPNAPYL
- Range
- 126-134
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
- Alternative Names
- WT1; Wilms tumor 1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1
- Gene ID
- 7490
- UniProt ID
- P19544
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Great WT1 Specific Detection
The PE-labeled HLA-A2 tetramer for WT1 (126-134) was perfect for our Wilms tumor research. We identified YMFPNAPYL-specific CD8 T cells in human samples. The signal was bright and specific, facilitating our analysis of this transcription factor.
Reliable Cancer Antigen Tool
We utilized this product to study immunity against Wilms tumor 1 protein. The tetramer showed excellent binding to the target T cells, allowing us to accurately quantify the antigen-specific population in our study cohort.
Q&As
-
What disease is the WT1 gene primarily associated with?
A: The WT1 gene (Wilms tumor 1) is a transcription factor that is essential for the development of the urogenital system. It is mutated in a subset of patients with Wilms tumor, a kidney cancer affecting children.
-
What peptide sequence is loaded into this HLA-A2 tetramer?
A: The peptide sequence is YMFPNAPYL, which corresponds to residues 126-134 of the human WT1 protein. This peptide is a target for CD8 T cells in HLA-A2 positive individuals.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
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Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| MOR-3886 | Rabbit Anti-WT1 Recombinant Antibody (clone DS3886AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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