Recombinant Human Anti-human PAPPA Antibody (CAT#: MHH-748)
Recombinant Human Antibody specifically reacts with Human PAPPA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-PAPPA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-PAPPA mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human placenta
(High expression. RNA expression: 72.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/ihc_selected.jpg
(High expression. RNA expression: 72.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/ihc_selected.jpg
Figure 2 IHC staining of human prostate
(Low expression. RNA expression: 1.1 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_2_5_val_selected.jpg
(Low expression. RNA expression: 1.1 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_2_5_val_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_B_7_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_B_7_5.jpg
Figure 4 Colon
(Glandular cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_9_3.jpg
(Glandular cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_9_3.jpg
Figure 5 Liver
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_9_4.jpg
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_9_4.jpg
Figure 6 Kidney
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_9_5.jpg
(Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_9_5.jpg
Figure 7 Testis
(Cells in seminiferous ducts
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_4_6.jpg
(Cells in seminiferous ducts
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_4_6.jpg
Figure 8 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_8_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1667/7481_A_8_8.jpg
Figure 9 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, HSkMC, U-138 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182752-PAPPA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182752-PAPPA
Specifications
- Immunogen
- Human pregnancy-associated plasma protein A, pappalysin 1
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Human pregnancy-associated plasma protein A, pappalysin 1
- Species Reactivity
- Human
- Applications
- Used for immunoassaytechniques such as: Immunoprecipitation; Immunofluorescence; Functional Study
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
- Alternative Names
- PAPPA; pregnancy-associated plasma protein A, pappalysin 1; PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase; pappalysin-1; IGF-dependent IGFBP-4 protease; aspecific BCL2 ARE-binding protein 2; pregnacy-associated plasma protein A; differentially placent
- Gene ID
- 5069
- UniProt ID
- Q13219
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-748 | Recombinant Anti-human PAPPA Antibody | ELISA, WB, FuncS | IgG |
| MOB-1532CT | Recombinant Mouse anti-Human PAPPA Monoclonal antibody (005-00) | ELISA, IHC-Fr, IHC-P, WB | |
| HPAB-1890-FY | Human Anti-PAPPA Recombinant Antibody (clone ABa01) | Inhib | Human IgG |
| HPAB-1891-FY | Human Anti-PAPPA Recombinant Antibody (clone ABa02) | Inhib | Human IgG |
| HPAB-1892-FY | Human Anti-PAPPA Recombinant Antibody (clone ABa03) | Inhib | Human IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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