Anti-PTK7-auristatin ADC
CAT#: ADC-118LZY
This ADC product is composed of an anti-PTK7 antibody conjugated via linker to auristatin (anti-PTK7-auristatin). It is in Phase I clinical trials and has demonstrated a response in Solid tumor treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specifications
- Antibody Overview
- Anti-PTK7 Antibody
- Drug
- auristatin
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
- Alternative Names
- PTK7; protein tyrosine kinase 7 (inactive); CCK4; CCK-4; inactive tyrosine-protein kinase 7; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; tyrosine-protein kinase-like 7; pseudo tyrosine kinase receptor 7;
- Gene ID
- 5754
- UniProt ID
- Q13308
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0356CT | Recombinant Mouse anti-Human PTK7 Monoclonal antibody (EML650) | WB | |
| HPAB-0027-LS | Human Anti-PTK7 Recombinant Antibody (HPAB-0027-LS) | ELISA, IB, FC, FuncS | Humanized IgG4 κ |
| HPAB-0028-LS | Human Anti-PTK7 Recombinant Antibody (HPAB-0028-LS) | ELISA, FC | Human IgG |
| VS3-XY1318 | Mouse Anti-PTK7 Recombinant Antibody (clone 4F9) | ELISA, WB, IHC | Mouse IgG1 |
| VS7-0425-WR716 | Mouse Anti-PTK7 Monoclonal Antibody (VS7-0425-WR716) | WB, IHC-P, IF, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0027-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0027-LS-F(E)) | ELISA | Humanized Fab |
| HPAB-0028-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0028-LS-F(E)) | ELISA, FC | Human Fab |
| HPAB-0029-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0029-LS-F(E)) | ELISA, FC | Human Fab |
| HPAB-0030-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0030-LS-F(E)) | ELISA, FC | Human Fab |
| HPAB-0031-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0031-LS-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0027-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0027-LS-S(P)) | ELISA | Humanized scFv |
| HPAB-0028-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0028-LS-S(P)) | ELISA, FC | Human scFv |
| HPAB-0029-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0029-LS-S(P)) | ELISA, FC | Human scFv |
| HPAB-0030-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0030-LS-S(P)) | ELISA, FC | Human scFv |
| HPAB-0031-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0031-LS-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY170 | Human Anti-PTK7 scFv-Fc Chimera (VS-0425-FY170) | WB, ELISA, IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC670 | Recombinant Anti-PTK7 Vesicular Antibody, EV Displayed (VS-0425-YC670) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5851 | Anti-PTK7 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5852 | Anti-Rat PTK7 Immunohistochemistry Kit | IHC |
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