Human Anti-ACKR3 Recombinant Antibody (VS-0724-YC10)

CAT#: VS-0724-YC10

Clones CID24 and CID25 are recombinant antibodies against human ACKR3 protein. CID24 fully occupies the cytoplasmic cleft of activated ACKR3 and efficiently blocks GRK2/5 phosphorylation of ACKR3. CID25 binds to an extracellular epitope that includes elements from both ACKR3 and CXCL12.

Gene Expression
Figure 1 IF staining of human cell line U-251 MG Figure 2 IHC staining of human placenta Figure 3 IF staining of human cell line HeLa Figure 4 Pancreas Figure 5 Kidney Figure 6 Testis Figure 7 RNA cell line category: Cell line enhanced (HeLa, MCF7, RT4, SiHa, U-2197)
Sub Cat Clone Applications Size Conjugation Endotoxin Purity Fc Engineering  
VS-0724-YC11 CID24 ELISA, Block
VS-0724-YC12 CID25 ELISA

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG
  • Specificity
  • Human ACKR3
  • Species Reactivity
  • Human

Product Property

  • Purification
  • Protein A purified
  • Purity
  • >95% as determined by SDS-PAGE and SEC-HPLC analysis
  • Buffer
  • PBS, pH 7.4
  • Preservative
  • No preservatives
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
  • Long Name
  • atypical chemokine receptor 3
  • Sequence Similarities
  • Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
  • Cellular Localization
  • Cell membrane, Endosome, Membrane
  • Post Translation Modifications
  • The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
    Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner.
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Isotype Control

Secondary Antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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