Does it recognize CXCR7?

Yes, ACKR3 is also known as CXCR7 (C-X-C chemokine receptor type 7). This antibody specifically recognizes this receptor and is validated for FC and IHC.

Anti-Human ACKR3 Recombinant Antibody (TAB-008MZ-VHH)

CAT#: TAB-008MZ-VHH

Recombinant monoclonal antibody to CXCR7, 08A10, is a human single domain antibody intended for the prophylaxis and treatment of related disease such as CXCR7 mediated tumour.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32003/1048_F7_2_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human placenta

Immunohistochemical staining of human placenta shows cytoplasmic positivity in trophoblasts.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49718/116961_A_2_7_selected.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line HeLa

Immunofluorescent staining of human cell line HeLa shows localization to plasma membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32003/1047_F7_1_blue_red_green.jpg

Normal Tissue Figure 4 Pancreas

Exocrine glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49718/116961_A_1_3.jpg

Normal Tissue Figure 5 Kidney

Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49718/116961_A_9_5.jpg

Normal Tissue Figure 6 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49718/116961_A_4_6.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enhanced (HeLa, MCF7, RT4, SiHa, U-2197)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000144476-ACKR3

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Specifications

Host Species
Llama

Derivation
Phage library

Type
Single domain antibody

Specificity
Human

Species Reactivity
Cynomolgus

Clone
TAB-008MZ-VHH

Applications
Flow Cytometry, Immunohistochemistry

Related Disease
Head and neck cancer

Target

Alternative Names
ACKR3; atypical chemokine receptor 3; RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159; G protein-coupled receptor; chemokine orphan receptor 1; G-protein coupled receptor 159; C-X-C chemokine receptor type 7; chemokine (C-X-C motif) receptor 7; G-protein coupled receptor RDC1 homolog

Gene ID
57007

UniProt ID
P25106

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

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Breast cancer biomarkers at key points during disease progression

Excellent Tissue Penetration

We used this single domain antibody for Immunohistochemistry on tissue sections. Its small size likely helped with penetration, giving us very crisp staining of CXCR7. It also worked well in Flow Cytometry.

Q&As

Does it recognize CXCR7?

A: Yes, ACKR3 is also known as CXCR7 (C-X-C chemokine receptor type 7). This antibody specifically recognizes this receptor and is validated for FC and IHC.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-008MZ-VHH.pdf

MSDS

MSDS - TAB-008MZ-VHH.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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TAB-172MZ	Mouse Anti-ACKR3 Recombinant Antibody (TAB-172MZ)	FC	Mouse IgG

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TAB-167MZ-S(P)	Anti-Human ACKR3 Recombinant Antibody scFv Fragment (6G2)	FC

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TAB-005MZ-VHH	Anti-Human ACKR3 Recombinant Antibody (TAB-005MZ-VHH)	FC, IHC	Single domain antibody

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TAB-006MZ-VHH	Anti-Human ACKR3 Recombinant Antibody (TAB-006MZ-VHH)	FC, IHC	Single domain antibody

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TAB-007MZ-VHH	Anti-Human ACKR3 Recombinant Antibody (TAB-007MZ-VHH)	FC, IHC	Single domain antibody

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TAB-009MZ-VHH	Anti-Human ACKR3 Recombinant Antibody (TAB-009MZ-VHH)	FC, IHC	Single domain antibody

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MOR-0892	Hi-Affi™ Rabbit Anti-ACKR3 Recombinant Antibody (clone DS892AB)	WB	Rabbit IgG

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VS-0325-FY134	Mouse Anti-ACKR3 scFv-Fc Chimera (VS-0325-FY134)	FC	Mouse IgG1, scFv-Fc

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VS-1025-YC114	Anti-ACKR3 Antibody Prodrug, Protease Activated (6G2)	ISZ, Cyt, FuncS

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