Mouse Anti-ADA Recombinant Antibody (VS3-CJ221)
CAT#: VS3-CJ221
This product is a mouse antibody that recognizes ADA (C-term).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/26_D7_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/27_D7_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/28_D7_1_blue_red_green.jpg
Normal Tissue
Figure 4 Duodenum
Enterocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Enterocytes - Microvilli
Staining: Medium
Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/162544_A_7_2.jpg
Normal Tissue
Figure 5 Testis
Round or early spermatids
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/162544_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196839-ADA
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Specifications
- Immunogen
- KLH-conjugated synthetic peptide between 287-314 amino acids from the C-terminal region of human ADA
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human ADA
- Species Reactivity
- Human
- Applications
- WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A/G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Preservative
- 0.09% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:4000).
Target
- Alternative Names
- ADA1
- Gene ID
- 100
- UniProt ID
- P00813
- Sequence Similarities
- Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
- Cellular Localization
- Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Lysosome, Membrane
- Protein Refseq
- NP_000013.2
- Function
- Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267).
Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412).
Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392).
Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity).
Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412).
Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172).
Stimulates plasminogen activation (PubMed:15016824).
Plays a role in male fertility (PubMed:21919946, PubMed:26166670).
Plays a protective role in early postimplantation embryonic development (By similarity).
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Related Diseases
Primary Immunodeficiency
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "ADA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1230z | Mouse Anti-ADA Recombinant Antibody (clone 20C10) | FC, IHC, WB | Mouse IgG2b |
| MRO-215-MZ | Mouse Anti-ADA Recombinant Antibody (clone ADA-1) | RIA, WB, IP | Mouse IgG |
| MOB-0430MZ | Recombinant Mouse Anti-Escherichia coli ada Antibody (clone BEB-2) | IP, RIA, WB | Mouse antibody |
| VS3-QX22 | Mouse Anti-ADA Recombinant Antibody (clone 608CT2.1.3) | WB | Mouse IgG1 |
| VS13-YC22 | Rabbit Anti-ADA Recombinant Antibody (VS13-YC22) | WB, ICC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0067 | Hi-Affi™ Rabbit Anti-ADA Recombinant Antibody (clone DS67AB) | ICC, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC242 | AbPlus™ Anti-ADA Magnetic Beads (VS-0724-YC242) | IP, Protein Purification | |
| VS-0724-YC262 | AbPlus™ Anti-ADA Magnetic Beads (VS-0724-YC262) | IP, Protein Purification |
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