Human Anti-Agr2 Recombinant Antibody (clone CPR02) (CAT#: VS-0524-YC26)
The antibody targets the recombinant Agr2 antigen (consisting of amino acid residues 41-175 of Agr2) which was confirmed by ELISA. Immunofluorescence analysis on colon biopsy samples from a healthy donor was performed to verify the ability of CPR02 to recognize the human Agr2 antigen.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/1873_D5_2_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/1873_D5_2_selected.jpg
Figure 2 IF staining of cell line RT4
(Immunofluorescent staining of cell line RT4 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/1386_F6_1_blue_red_green.jpg
(Immunofluorescent staining of cell line RT4 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/1386_F6_1_blue_red_green.jpg
Figure 3 Colon
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining:Medium
Intensity: Moderate
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/24377_A_9_3.jpg
(Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining:Medium
Intensity: Moderate
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/24377_A_9_3.jpg
Figure 4 Prostate
(Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/24377_A_3_5.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7912/24377_A_3_5.jpg
Specifications
- Host Species
- Human
- Derivation
- Antibody phage display
- Type
- Human IgG
- Specificity
- Human anterior gradient protein 2 homolog (Agr2)
- Species Reactivity
- Human
- Clone
- CPR02
- Applications
- ELISA, IF
Product Property
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservative
- Storage
- Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Anterior Gradient 2, Protein Disulphide Isomerase Family Member; Protein Disulfide Isomerase Family A, Member 17; Secreted Cement Gland Protein XAG-2 Homolog; HAG-2; AG-2; HPC8; AG2; Anterior Gradient 2 Homolog (Xenopus Laevis); Anterior Gradient Protein 2 Homolog
- Gene ID
- 10551
- UniProt ID
- O95994
- Long Name
- Anterior Gradient Protein 2 Homolog (Agr2)
- Sequence Similarities
- Belongs to the AGR family.
- Cellular Localization
- Endoplasmic reticulum
- Post Translation Modifications
- Disulfide bond
- Protein Refseq
- NP_006399.1
- Function
- Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity).
Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.
Recommended Products
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-130-VHH | Recombinant Anti-Human AGR2 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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