Mouse Anti-ANXA1 Recombinant Antibody (clone ABT-ANXA1)
CAT#: VS3-CJ327
This product is a mouse antibody that recognizes ANXA1.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/108_D12_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11272/85_H11_2_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13023/if_selected.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35987/265_B3_1_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_B_7_5.jpg
Normal Tissue
Figure 6 Esophagus
Squamous epithelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_B_4_1.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11271/29847_A_8_5.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135046-ANXA1
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Specifications
- Immunogen
- Synthesized peptide derived from human Annexin A1
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human ANXA1
- Species Reactivity
- Human
- Clone
- ABT-ANXA1
- Applications
- IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- ANX1; LPC1; Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
- Gene ID
- 301
- UniProt ID
- P04083
- Sequence Similarities
- Belongs to the annexin family.
- Cellular Localization
- Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle
- Post Translation Modifications
- Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879).
Phosphorylated in response to EGF treatment (PubMed:2532504).
Sumoylated.
Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26.
- Protein Refseq
- NP_000691.1
- Function
- Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544).
Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity).
Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549).
Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549).
Has no effect on unstimulated T cells (PubMed:17008549).
Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660).
Has high affinity for Ca2+ and can bind up to eight Ca2+ ions (By similarity).
Displays Ca2+-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678).
Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
Annexin Ac2-26:
Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:22879591, PubMed:15187149, PubMed:25664854).
Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149).
Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149).
Promotes resolution of inflammation and wound healing (PubMed:25664854).
Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "ANXA1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0923CLV | Human Anti-ANXA1 Recombinant Antibody (TAB-0923CLV) | ELISA | Human IgG |
| TAB-0923CLV-F(E) | Human Anti-ANXA1 Recombinant Antibody; Fab Fragment (TAB-0923CLV-F(E)) | ELISA | Human Fab |
| TAB-0923CLV-S(P) | Human Anti-ANXA1 Recombinant Antibody; scFv Fragment (TAB-0923CLV-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0924CLV | Mouse Anti-ANXA1 Recombinant Antibody (TAB-0924CLV) | FuncS | Mouse IgG2b |
| TAB-0924CLV-F(E) | Mouse Anti-ANXA1 Recombinant Antibody; Fab Fragment (TAB-0924CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0924CLV-S(P) | Mouse Anti-ANXA1 Recombinant Antibody; scFv Fragment (TAB-0924CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0182 | Hi-Affi™ Rabbit Anti-ANXA1 Recombinant Antibody (clone DS182AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1973 | PE-B7/Human ANXA1 (KPAFFAEKL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0914-WJ | Mouse Anti-ANXA1 Recombinant Antibody (HPAB-0914-WJ) | ELISA | Mouse IgG2b |
| VS3-CJ328 | Mouse Anti-ANXA1 Recombinant Antibody (clone PT1761) | IHC-P | Mouse IgG1, κ |
| VS3-CJ329 | Mouse Anti-ANXA1 Recombinant Antibody (VS3-CJ329) | IHC | Mouse IgG1 |
| VS-0923-FY13 | Recombinant Mouse Anti-ANXA1 Antibody (VS-0923-FY13) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-FY2625 | Rabbit Anti-ANXA1 Recombinant Antibody (VS3-FY2625) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0914-WJ-S(P) | Mouse Anti-ANXA1 Recombinant Antibody; scFv Fragment (HPAB-0914-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0914-WJ-F(E) | Mouse Anti-ANXA1 Recombinant Antibody; Fab Fragment (HPAB-0914-WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY28 | Human Anti-ANXA1 scFv-Fc Chimera (VS-0325-FY28) | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY116 | Anti-ANXA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY406 | Anti-Mouse ANXA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY405 | Anti-Human ANXA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY407 | Anti-Rat ANXA1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC18 | Recombinant Anti-ANXA1 Eliminating Antibody, pH-Sensitive (SAIC-13C-5G10 var.) | Antigen-Sweeping In Vivo. | Mouse IgG1 |
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