Mouse Anti-AREG Recombinant Antibody (clone 6E11 1E9 1C6)
CAT#: VS-0624-FY2
This mouse recombinant antibody demonstrates affinity towards human AREG. The immunogen utilized in the production of this antibody is the recombinant HBEGF protein, a crucial paralog of the AREG gene.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23519/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong membranous positivity in cytotrophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_1_7_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_6_6.jpg
Normal Tissue
Figure 7 Placenta
Trophoblastic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_1_7.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (CACO-2, HBEC3-KT, hTCEpi, hTERT-HME1, MCF7)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000109321-AREG
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Specifications
- Immunogen
- The recombinant HBEGF protein.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human AREG
- Species Reactivity
- Human
- Clone
- 6E11 1E9 1C6
- Applications
- ELISA
- Related Disease
- Ovarian Cystadenoma and Psoriasis
Product Property
- Clonality
- Monoclonal Antibody
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Amphiregulin; Colorectum Cell-Derived Growth Factor; Schwannoma-Derived Growth Factor; Amphiregulin B; AREGB; CRDGF; SDGF; AR
- Gene ID
- 374
- UniProt ID
- P15514
- Long Name
- Amphiregulin
- Sequence Similarities
- Belongs to the amphiregulin family.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn30, Ser41, Thr52, Ser53, Asn113, Asn119, and Thr169 (NX_P15514 [NX_P15514-1])
Modification sites at PhosphoSitePlus (P15514)
Glycosylation from GlyGen (P15514) 8 sites, 1 O-linked glycan (5 sites)
- Protein Refseq
- NP_001648.1
- Function
- Ligand of the EGF receptor/EGFR.
Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "AREG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3885z | Mouse Anti-AREG Recombinant Antibody (clone 43B6) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MOB-0613MZ | Mouse Anti-AREG Recombinant Antibody (clone NN0090-9L27) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0037MZ | Chicken Anti-Amphiregulin Polyclonal IgY | WB | Chicken antibody |
| BRD-0939MZ | Chicken Anti-Amphiregulin Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-025CQ | Mouse Anti-AREG Recombinant Antibody (clone CBL747) | WB, ELISA(Cap), Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY145 | Anti-AREG Immunohistochemistry Kit | IHC | |
| VS-0525-XY493 | Anti-Rat AREG Immunohistochemistry Kit | IHC | |
| VS-0525-XY492 | Anti-Human AREG Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC331 | Recombinant Anti-AREG Vesicular Antibody, EV Displayed (VS-0425-YC331) | ELISA, FC, Cell-uptake |
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