Mouse Anti-AREG Recombinant Antibody (clone 6E11 1E9 1C6) (CAT#: VS-0624-FY2)
This mouse recombinant antibody demonstrates affinity towards human AREG. The immunogen utilized in the production of this antibody is the recombinant HBEGF protein, a crucial paralog of the AREG gene.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23519/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23519/if_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong membranous positivity in cytotrophoblastic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_1_7_selected.jpg
(Immunohistochemical staining of human placenta shows strong membranous positivity in cytotrophoblastic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_1_7_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_B_7_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_B_7_5.jpg
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_7_3.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_8_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_8_5.jpg
Figure 6 Testis
(Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_6_6.jpg
(Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_6_6.jpg
Figure 7 Placenta
(Trophoblastic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_1_7.jpg
(Trophoblastic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_1_7.jpg
Figure 8 RNA cell line category: Cell line enhanced (CACO-2, HBEC3-KT, hTCEpi, hTERT-HME1, MCF7)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000109321-AREG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000109321-AREG
Specifications
- Immunogen
- The recombinant HBEGF protein.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human AREG
- Species Reactivity
- Human
- Clone
- 6E11 1E9 1C6
- Applications
- ELISA
- Related Disease
- Ovarian Cystadenoma and Psoriasis
Product Property
- Clonality
- Monoclonal Antibody
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Amphiregulin; Colorectum Cell-Derived Growth Factor; Schwannoma-Derived Growth Factor; Amphiregulin B; AREGB; CRDGF; SDGF; AR
- Gene ID
- 374
- UniProt ID
- P15514
- Long Name
- Amphiregulin
- Sequence Similarities
- Belongs to the amphiregulin family.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn30, Ser41, Thr52, Ser53, Asn113, Asn119, and Thr169 (NX_P15514 [NX_P15514-1])
Modification sites at PhosphoSitePlus (P15514)
Glycosylation from GlyGen (P15514) 8 sites, 1 O-linked glycan (5 sites)
- Protein Refseq
- NP_001648.1
- Function
- Ligand of the EGF receptor/EGFR.
Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3885z | Mouse Anti-AREG Recombinant Antibody (clone 43B6) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MOB-0613MZ | Mouse Anti-AREG Recombinant Antibody (clone NN0090-9L27) | WB | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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