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AREG

Anti-AREG Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
Protein class

Cancer-related genes, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Urothelial cells, Macrophages, Basal prostatic cells, Basal keratinocytes, Paneth cells)

Immune cell specificity

Group enriched (eosinophil, basophil, NK-cell)

Cell line specificity

Cell line enhanced (CACO-2, HBEC3-KT, hTCEpi, hTERT-HME1, MCF7)

Interaction

The immature precursor interacts with CNIH.

Molecular function

Cytokine, Growth factor

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