Recombinant Anti-AREG Vesicular Antibody, EV Displayed (VS-0425-YC331)
CAT#: VS-0425-YC331
The Recombinant Anti-AREG Vesicular Antibody, EV Displayed (VS-0425-YC331) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to AREG-expressed cells or tissues. The AREG is a growth factor influencing epithelial cell growth and cancer progression, linked to inflammatory conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23519/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong membranous positivity in cytotrophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_1_7_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Preleptotene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_6_6.jpg
Normal Tissue
Figure 7 Placenta
Trophoblastic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8720/156789_A_1_7.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (CACO-2, HBEC3-KT, hTCEpi, hTERT-HME1, MCF7)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000109321-AREG
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- AREG
- Host Animal
- Human
- Antibody Isotype
- IgG1
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Amphiregulin
- Molecular Function
- Cytokine, Growth factor
- Cellular Localization
- Mitochondria
- Introduction
- The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
- Alternative Names
- AR, AREGB, SDGF
- Gene ID
- 374
- UniProt ID
- P15514
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "AREG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3885z | Mouse Anti-AREG Recombinant Antibody (clone 43B6) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MOB-0613MZ | Mouse Anti-AREG Recombinant Antibody (clone NN0090-9L27) | WB | Mouse IgG1 |
| VS-0624-FY2 | Mouse Anti-AREG Recombinant Antibody (clone 6E11 1E9 1C6) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0037MZ | Chicken Anti-Amphiregulin Polyclonal IgY | WB | Chicken antibody |
| BRD-0939MZ | Chicken Anti-Amphiregulin Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-025CQ | Mouse Anti-AREG Recombinant Antibody (clone CBL747) | WB, ELISA(Cap), Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY145 | Anti-AREG Immunohistochemistry Kit | IHC | |
| VS-0525-XY493 | Anti-Rat AREG Immunohistochemistry Kit | IHC | |
| VS-0525-XY492 | Anti-Human AREG Immunohistochemistry Kit | IHC |
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