Mouse Anti-ARG1 Recombinant Antibody (VS3-CJ391)
CAT#: VS3-CJ391
This product is a mouse antibody that recognizes ARG1.
Gene Expression
Normal Tissue
Figure 1 High expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3595/10647_A_8_4_val_selected.jpg
Normal Tissue
Figure 2 Low expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3595/10647_A_3_3_val_selected.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/80011/171017_A_7_4.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/80011/171017_B_6_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HL-60)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118520-ARG1
❮
❯
Specifications
- Immunogen
- KLH-conjugated synthetic peptide encompassing a sequence within human Arginase 1
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human ARG1
- Species Reactivity
- Human
- Applications
- IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Immunogen affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.2% BSA, PBS.
- Preservative
- 0.01% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry (1:100-1:300).
Target
- Alternative Names
- Arginase-1; Liver-type arginase; Type I arginase
- Gene ID
- 383
- UniProt ID
- P05089
- Sequence Similarities
- Belongs to the arginase family.
- Cellular Localization
- Cytoplasm
- Protein Refseq
- NP_000036.2; NP_001231367.1
- Function
- Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.
Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772).
In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity).
In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-CJ391. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "ARG1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1251MZ | Mouse Anti-ARG1 Recombinant Antibody (clone 5F7) | FC, IHC-P, WB | Mouse IgG1 |
| ZG-0036J | Mouse Anti-ARG1 Recombinant Antibody (ZG-0036J) | IHC-P, IF | Mouse IgG |
| VS3-CJ390 | Mouse Anti-ARG1 Recombinant Antibody (VS3-CJ390) | WB, IHC | Mouse IgG2b |
| VS3-CJ392 | Rabbit Anti-ARG1 Recombinant Antibody (VS3-CJ392) | WB, IP | Rabbit IgG |
| VS3-FY2627 | Mouse Anti-ARG1 Recombinant Antibody (VS3-FY2627) | WB, ICC, FC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0686MZ | Chicken Anti-ARG1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0238 | Hi-Affi™ Rabbit Anti-ARG1 Recombinant Antibody (clone DS238AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY18 | AbPlus™ Anti-ARG1 Magnetic Beads (JB21-49) | IP, Protein Purification | |
| VS-0724-YC1258 | AbPlus™ Anti-ARG1 Magnetic Beads (VS-0724-YC1258) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY153 | Anti-ARG1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY498 | Anti-Mouse ARG1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY497 | Anti-Human ARG1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY499 | Anti-Rat ARG1 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FC, IHC-Fr, IP, ELISA, Block
Application: ELISA, Inhib, FuncS
Application: ELISA, PD, Activ, PK, Stim
Application: IF, IP, Neut, FuncS, ELISA, FC
-3.jpg)
Application: IB, FC, ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
