Anti-ARG1 Recombinant Antibody Products

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Anti-ARG1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a world leader in immuno-oncology and metabolic disease research. We are proud to offer you premium anti-Arginase 1 (ARG1) recombinant antibodies for use in cancer immunology and metabolism. ARG1 is a major suppressor of T-cell function in the tumor microenvironment and depletes arginine to do so. Our highly specific anti-ARG1 antibodies are a crucial tool for the study of this mechanism and to help researchers develop new cancer immunotherapies.

ARG1: A Key Metabolic Checkpoint in Tumor Immunity

Arginase 1 (ARG1) is a cytosolic enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. ARG1 is best known for its essential role in the liver urea cycle but, it is also a major player in tumor immunity. Myeloid-derived suppressor cells (MDSCs) overexpress ARG1 in the tumor microenvironment and, through local arginine depletion, essentially starve anti-tumor T cells of this essential amino acid, shutting them down. Inhibition of ARG1 function is, therefore, a promising strategy to restore T-cell function and make other immunotherapies work better.

Alternative Names

Arginase 1; Liver-Type Arginase; Arginase, Liver; Type I Arginase; EC 3.5.3.1; Arginase-1

Background

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.

Anti-ARG1 rAb Products

Our recombinant antibodies to ARG1 are custom-made for maximal specificity and sensitivity. They are extensively validated to work for detection of ARG1 in cell lysates and tissue sections, making them the perfect tool to identify and characterize MDSCs. Our anti-ARG1 rAbs are optimized for use in IHC and flow cytometry, and will provide you with bright, clean signals for these applications.

Table 1. Featured anti-ARG1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Quality is a way of life at Creative Biolabs. The production of our recombinant antibodies to ARG1 is no exception. We use an exacting quality control process and every lot of anti-ARG1 antibodies is thoroughly tested for purity, binding affinity, and lot-to-lot consistency in the validated applications we provide so you can be sure you are getting a high quality reagent that will generate high quality data.

Customer Reviews

Excellent

Th*s
Mouse Anti-ARG1 Recombinant Antibody (ZG-0036J)

I used the anti-ARG1 antibody from Creative Biolabs to identify MDSCs in our tumor model by IHC. The staining was so specific and it made it easy to quantify.

22/Dec/2024

rAb Production

Creative Biolabs is driven by the rapid progress in the field of immuno-oncology and uses state-of-the-art production platforms to make our products. We express our anti-ARG1 recombinant antibodies using systems that have been optimized to ensure they will recognize the native protein accurately. This high-tech approach means we can deliver a high activity, highly specific antibody that meets your research needs.

Featured Anti-ARG1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-ARG1 recombinant antibody production.

Fig.3 Gram-scale anti-ARG1 recombinant antibody production.

rAb Modalities

At Creative Biolabs, we are committed to being innovative and flexible to meet the needs of the immunology research community. Our anti-ARG1 recombinant antibodies are available in a variety of formats and modalities, from different isotypes to conjugations, and can be customized to fit your experimental design and provide you with the tools you need to dissect this important metabolic checkpoint.

Fig.4 Full-length anti-ARG1 recombinant antibody production and modalities.

Unlock the full potential of the immune system by studying ARG1-mediated T cell suppression with Creative Biolabs' top-tier recombinant antibodies. Our products are defined by extensive validation and stellar performance, making them the ideal tools for your cancer immunology research. Trust us to help power your next discovery. Contact our experts today.