Human Anti-B. anthracis PA Recombinant Antibody (clone 001.46F1) (CAT#: FAMAB-0333JF)
Recombinant monoclonal antibody specially binds to Bacillus anthracis protective antigen (PA). This human anti-PA antibody (001.46F1) can be potencially used in the treatment of patients with Bacillus anthracis infection.
Specific Inquiry
ELISA
Figure 1 In vitro germination of antibody-treated spores.
Samples were removed at intervals to assess the extent of germination by the decline (percentage change) in the OD560.
Welkos, S., Little, S., Friedlander, A., Fritz, D., & Fellows, P. (2001). The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores. Microbiology, 147(6), 1677-1685.
IHC
Figure 2 Detection of PA associated with spores by immunogold labelling and electron microscopy.
Arrow shows the frequently observed peripheral location of the gold in Ames-H spores. Bars, 500 nm.
Welkos, S., Little, S., Friedlander, A., Fritz, D., & Fellows, P. (2001). The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores. Microbiology, 147(6), 1677-1685.
WB
Figure 3 Detection of proteins recognized by rabbit anti-rPA IgG and mouse anti-PA mAbs in spore surface extracts.
Extracts from germinated spores were also analysed by using a mixture of two mAbs to PA.
Welkos, S., Little, S., Friedlander, A., Fritz, D., & Fellows, P. (2001). The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores. Microbiology, 147(6), 1677-1685.
Specifications
- Immunogen
- AVA (anthrax vaccine)
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- Bacillus anthracis PA
- Species Reactivity
- B. anthracis
- Clone
- 001.46F1
- Applications
- ELISA, IHC
- Related Disease
- Bacillus anthracis infection
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The B. anthracis PA antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Immunohistochemistry.
Target
- Alternative Names
- Protective antigen; PA
- Function
- Neutralization activity
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-194-VHH | Recombinant Anti-B. anthracis PA VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-224 | Anti-B. Anthracis Anthrax Protective Antigen (Raxibacumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - lambda |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-97-F(E) | Recombinant Human Anti-B. anthracis PA Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| HPAB-0780-CN-F(E) | Mouse Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-0780-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-1646-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-1646-FY-S(P)) | ELISA | Human scFv |
| HPAB-1647-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-1647-FY-S(P)) | ELISA | Human scFv |
| HPAB-1648-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-1648-FY-S(P)) | ELISA | Human scFv |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0387LC | Recombinant Mouse Anti-B. anthracis PA Antibody (F20G75) | BL, ELISA | IgG1 |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0780-CN | Mouse Anti-B. anthracis PA Recombinant Antibody (HPAB-0780-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0781-CN | Mouse Anti-B. anthracis PA Recombinant Antibody (HPAB-0781-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-1824-FY | Human Anti-B. anthracis PA Recombinant Antibody (clone 21D9) | Inhib | Human IgG |
| HPAB-1825-FY | Human Anti-B. anthracis PA Recombinant Antibody (clone 1C6) | Inhib | Human IgG |
| HPAB-1826-FY | Human Anti-B. anthracis PA Recombinant Antibody (clone 4H7) | ELISA | Human IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-224 | Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-440CQ | Afuco™ Anti-PA ADCC Recombinant Antibody (Obiltoxaximab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1646-FY-F(E) | Human Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-1646-FY-F(E)) | ELISA | Human Fab |
| HPAB-1647-FY-F(E) | Human Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-1647-FY-F(E)) | ELISA | Human Fab |
| HPAB-1648-FY-F(E) | Human Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-1648-FY-F(E)) | ELISA | Human Fab |
| HPAB-0747-YJ-S(P) | Chimpanzee Anti-PA Recombinant Antibody (W1); scFv Fragment | ELISA, Neut | Chimpanzee scFv |
| FAMAB-0333JF-S(P) | Human Anti-B. anthracis PA Recombinant Antibody (clone 001.46F1); scFv Fragment | ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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