Recombinant Human Anti-C. albicans Antibody (λ2-18) (CAT#: FAMAB-0041YC)
Provided are antibodies detected C. albicans antigens by indirect immunofluorescence assay, enzyme-linked immunosorbent assay ELISA, and Western blotting. The antigens containing the epitopes recognized by the antibody could be extracted from blastoconidia by dithiothreitol, suggesting attachment to the cell wall via sulfhydryl bonds. Epitope detection by the antibody was sensitive to treatment of C.albicans blastoconidia with sodium periodate, but not proteinase K, indicating the cognate epitopes were composed of carbohydrate.
Specific Inquiry
IF
Figure 1 Human Anti-C. albicans Antibody (λ2-18) in IF.
IFA detection of binding of scFv5 and scFv12 to Candida species. Paired panels are immunofluorescent and bright-field photomicrographs of the same microscopic fields. (A) scFv λ2-18 binding to C. albicans, showing the highest intensity for binding to the blastoconidia as previously described.
Bliss, J. M., Sullivan, M. A., Malone, J., & Haidaris, C. G. (2003). Differentiation of Candida albicans and Candida dubliniensis by using recombinant human antibody single-chain variable fragments specific for hyphae. Journal of clinical microbiology, 41(3), 1152-1160.
IF
Figure 2 Human Anti-C. albicans Antibody (λ2-18) in IF.
IFA detection of scFv5 and scFv12 binding to C. albicans after proteinase K treatment. Paired panels are immunofluorescent and bright-field photomicrographs of the same microscopic fields. C. albicans filaments were subjected to proteinase K digestion, and the presence of antigen was detected by IFA. Mock-treated cells were treated with buffer alone. scFv λ2-18 has previously been shown to recognize a carbohydrate epitope.
Bliss, J. M., Sullivan, M. A., Malone, J., & Haidaris, C. G. (2003). Differentiation of Candida albicans and Candida dubliniensis by using recombinant human antibody single-chain variable fragments specific for hyphae. Journal of clinical microbiology, 41(3), 1152-1160.
Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG
- Specificity
- C. albicans
- Species Reactivity
- C. albicans
- Clone
- λ2-18
- Applications
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Target
- Alternative Names
- Candida albicans; C. albicans
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-132 | Recombinant Anti-C. albicans Antibody | ELISA, WB, FuncS | IgG |
| MHH-132 | Recombinant Human Anti-C. albicans Antibody | RIA, ELISA, FuncS | IgG |
| MOB-0086MZ | Recombinant Mouse Anti-Candida albicans Antibody (clone C342M) | ELISA, WB | Mouse antibody |
| FAMAB-0040YC | Recombinant Human Anti-C. albicans Antibody (λ2-9) | ELISA, IF, IHC, WB | Human IgG |
| FAMAB-0207JF | Mouse Anti-C. albicans Recombinant Antibody (clone 3B4) | WB, ELISA, IHC, IF | Mouse IgM |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-132-F(E) | Recombinant Anti-C. albicans Antibody Fab Fragment | WB, FuncS | Fab |
| MHH-132-F(E) | Recombinant Human Anti-C. albicans Antibody Fab Fragment | ELISA, IF, FuncS | Fab |
| FAMAB-0040-YC-F(E) | Recombinant Human Anti-C. albicans Antibody Fab Fragment (λ2-9) | ELISA, IF, IHC, WB | Human Fab |
| FAMAB-0041-YC-F(E) | Recombinant Human Anti-C. albicans Antibody Fab Fragment (λ2-18) | ELISA, IF, IHC, WB | Human Fab |
| FAMAB-0042-YC-F(E) | Recombinant Human Anti-C. albicans Antibody Fab Fragment (κ3-1) | ELISA, IF, IHC, WB | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-132-S(P) | Recombinant Anti-C. albicans Antibody scFv Fragment | WB, FC, FuncS | scFv |
| FAMAB-0040-YC-S(P) | Recombinant Human Anti-C. albicans Antibody scFv Fragment (λ2-9) | ELISA, IF, IHC, WB | Human scFv |
| FAMAB-0041-YC-S(P) | Recombinant Human Anti-C. albicans Antibody scFv Fragment (λ2-18) | ELISA, IF, IHC, WB | Human scFv |
| FAMAB-0042-YC-S(P) | Recombinant Human Anti-C. albicans Antibody scFv Fragment (κ3-1) | ELISA, IF, IHC, WB | Human scFv |
| FAMAB-0207JF-S(P) | Mouse Anti-C. albicans Recombinant Antibody (clone 3B4); scFv Fragment | ELISPOT, FACS, FC, IF, WB, ELISA, FuncS | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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