Human Anti-C2 Recombinant Antibody Hexamer (VS-0924-YC101), CDC Enhanced (CAT#: VS-0924-YC101)

• Host Species
• Human

• Derivation
• Humanized

• Type
• Antibody hexamer

• Specificity
• Human C2

• Species Reactivity
• Human

• Molecule Class
• ~ 900 kDa

• Applications
• ELISA, Inhib, CDC

• Conjugate
• None

• Related Disease
• Inflammatory disease, Neuro-inflammatory disease

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Purity
• >95% determined as SDS-PAGE and SEC-HPLC

• Aggregation
• <5%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

• Alternative Names
• C2; complement component 2; CO2; ARMD14; complement C2; C3/C5 convertase; complement component C2

• Gene ID
• 717

• UniProt ID
• P06681

• Long Name
• Complement C2

• Sequence Similarities
• Belongs to the peptidase S1 family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Asn29, Asn112, Asn333, Asn290, Asn467, Asn471, Asn621, and Asn651 ( NX_P06681 [NX_P06681-1] )

• Protein Refseq
• NP_000054.2; NP_001139375.1; NP_001171534.1

• Function
• Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a.
  C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

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