Human Anti-C2 Recombinant Antibody Hexamer (VS-0924-YC101), CDC Enhanced (CAT#: VS-0924-YC101)
The product is a human anti-C2 antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This IgG1 hexamer targets human complement C2 and includes mutations that enhance hexamerization. These specific mutations promote hexamer formation, facilitating optimal C1q binding and boosting CDC efficacy.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (Karpas-707)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000166278-C2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000166278-C2
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Antibody hexamer
- Specificity
- Human C2
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, Inhib, CDC
- Conjugate
- None
- Related Disease
- Inflammatory disease, Neuro-inflammatory disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- C2; complement component 2; CO2; ARMD14; complement C2; C3/C5 convertase; complement component C2
- Gene ID
- 717
- UniProt ID
- P06681
- Long Name
- Complement C2
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn29, Asn112, Asn333, Asn290, Asn467, Asn471, Asn621, and Asn651 ( NX_P06681 [NX_P06681-1] )
- Protein Refseq
- NP_000054.2; NP_001139375.1; NP_001171534.1
- Function
- Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a.
C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
Related Resources
Systemic Lupus Erythematosus
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1331CL-S(P) | Mouse Anti-C2 Recombinant Antibody; scFv Fragment (TAB-1331CL-S(P)) | ELISA | Mouse scFv |
| TAB-1332CL-S(P) | Mouse Anti-C2 Recombinant Antibody; scFv Fragment (TAB-1332CL-S(P)) | ELISA | Mouse scFv |
| TAB-1336CL-S(P) | Mouse Anti-C2 Recombinant Antibody; scFv Fragment (TAB-1336CL-S(P)) | FuncS | Mouse scFv |
| TAB-1337CL-S(P) | Mouse Anti-C2 Recombinant Antibody; scFv Fragment (TAB-1337CL-S(P)) | FuncS | Mouse scFv |
| TAB-1338CL-S(P) | Mouse Anti-C2 Recombinant Antibody; scFv Fragment (TAB-1338CL-S(P)) | Inhib, WB | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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