Mouse Anti-C2 Recombinant Antibody Hexamer (VS-0924-YC102), CDC Enhanced
CAT#: VS-0924-YC102
The product is a hexameric mouse anti-C2 antibody with enhanced CDC activity. This IgG1 antibody targets human C2 and contains hexamerization-enhancing mutations that promote hexamer formation, facilitating optimal C1q binding and boosting complement-dependent cytotoxicity (CDC).
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000166278-C2
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Specifications
- Immunogen
- Deglycosylated purified human C2
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human C2
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- CDC
- Conjugate
- None
- Related Disease
- Inflammatory disease, neuro-inflammatory disease or ischemia-reperfusion (I/R) injury
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- C2; complement component 2; CO2; ARMD14; complement C2; C3/C5 convertase; complement component C2
- Gene ID
- 717
- UniProt ID
- P06681
- Long Name
- Complement C2
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn29, Asn112, Asn333, Asn290, Asn467, Asn471, Asn621, and Asn651 ( NX_P06681 [NX_P06681-1] )
- Protein Refseq
- NP_000054.2; NP_001139375.1; NP_001171534.1
- Function
- Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a.
C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
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Related Diseases
Systemic Lupus Erythematosus
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC101 | Human Anti-C2 Recombinant Antibody Hexamer (VS-0924-YC101), CDC Enhanced | ELISA, Inhib, CDC | Antibody hexamer |
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