Mouse Anti-CCN1 Recombinant Antibody (clone 093G9); Fab Fragment
CAT#: PFBC-443
This product is a recombinant Mouse antibody Fab fragment that can recognize CCN1. 093G9, is effective to antagonize the effects of CCN1 and hence has potential therapeutic benefits against rheumatoid arthritis. The epitope recognized by 093G9 is mapped to residues 77 to 80 of CCN1, and a peptide encompassing residues 75 to 81 of CCN1 displays high binding affinity for 093G9.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29853/68976_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29853/68976_A_8_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29853/68976_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29853/68976_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29853/68976_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, EFO-21, SiHa, TIME, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000142871-CCN1
❮
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Specifications
- Host Species
- Mouse
- Type
- Mouse Fab
- Specificity
- Human CCN1
- Species Reactivity
- Human
- Clone
- 093G9
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Well Characterized Epitope
This Fab fragment is excellent because the epitope is well-mapped to residues 77-80 of CCN1. This level of detail allowed us to design very specific experiments. We confirmed its binding affinity using peptide competition assays, which matched the product description perfectly.
Effective CCN1 Antagonist
We used this antibody fragment (clone 093G9) in our neutralization assays. It effectively antagonized the effects of CCN1 in our cell culture model. It is a potent tool for researching the therapeutic potential of targeting CCN1 in conditions like rheumatoid arthritis.
Q&As
-
Does this antibody fragment have therapeutic potential in research?
A: This recombinant Mouse Fab fragment (clone 093G9) is effective to antagonize the effects of CCN1 and is being researched for potential therapeutic benefits against rheumatoid arthritis in experimental models.
-
What is the specific epitope recognized by this antibody?
A: The epitope recognized by this clone (093G9) is mapped to residues 77 to 80 of the CCN1 protein. A peptide encompassing residues 75 to 81 of CCN1 displays high binding affinity for this antibody fragment.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 093G9"
- CAT
- Product Name
See other products for "CCN1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-443 | Mouse Anti-CCN1 Recombinant Antibody (clone 093G9) | Inhib, FC, ELISA, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-443 | Mouse Anti-CCN1 Recombinant Antibody (clone 093G9); scFv Fragment | ELISA, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1072 | Anti-CCN1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1073 | Anti-Mouse CCN1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC51 | Recombinant Anti-CCN1 Eliminating Antibody, pH-Sensitive (093G9 var.) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
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